Changes and influencing factors of bone mineral density in female patients with thyroid disease
Objective To analyze the changes of bone mineral density in female patients with thyroid disease and its influencing factors.Methods 112 female patients with thyroid diseases were selected,and the bone mineral density of the patients was detected and divided into the reduced group(68 cases)and normal group(44 cases)according to the relevant standards.The influencing factors leading to changes in bone mineral density of female patients with thyroid disease were analyzed by unifactorial and multifactorial analysis.Results Among the 112 female patients with thyroid disease,osteopenia occurred in 56 cases,osteoporosis in 12 cases,with a total of 68 cases of reduced bone mineral density(reduced group),accounting for 60.71%(68/112);there were 44 cases of normal bone mass(normal group),accounting for 39.29%(44/112).In the reduced group,the percentage of combined diabetes was 38.24%,the percentage of menopause was 51.47%,the serum thyroid-stimulating hormone(TSH)was(5.36±0.52)mIU/L,the serum alkaline phosphatase(ALP)was(149.27±13.81)U/L,and the serum fibroblast growth factor 23(FGF23)was(103.84±9.58)ng/L,which were higher than 18.18%,27.27%,(4.95±0.51)mIU/L,(133.75±12.32)U/L,and(97.67±7.68)ng/L in the normal group,and the difference was statistically significant(P<0.05).There was no significant difference in comparison of age,body mass index(BMI),education level,place of residence,smoking history,drinking history,hypertension,hyperlipidemia,serum hypersensitive C-reactive protein(hs-CRP)level and serum serum albumin(ALB)level between the two groups(P>0.05).Single Logistic regression analysis showed that diabetes mellitus,menopause,high serum TSH level,high serum ALP level and high serum FGF23 level were all risk factors for reduced bone mineral density in female patients with thyroid disease(OR=2.786,2.828,4.570,1.093,1.083).Multivariate Logistic regression analysis showed that diabetes,menopause,high serum TSH level,high serum ALP level and high serum FGF23 level were independent risk factors for reduced bone mineral density in female thyroid disease patients(OR=4.463,4.145,4.255,1.100,1.109).Conclusion The influencing factors of reduced bone mineral density in female patients with thyroid disease may be related to diabetes,menopause,high serum TSH level,high serum ALP level,and high serum FGF23 level.
万方数据
维普
