Objective To analyze the diagnostic value of pepsinogen Ⅰ(PG-Ⅰ),pepsinogen Ⅱ(PG-Ⅱ),gastrin-17(G-17)combined with Helicobacter pylori immunoglobulin G(IgG)antibody in gastric cancer.Methods A total of 76 patients with gastric cancer were selected as the gastric cancer group,and 114 healthy volunteers were selected as the control group.PGⅠ,PGⅡ,G-17,and Helicobacter pylori IgG antibody tests were performed on all study subjects included in this study.The the level of PGⅠ,PGⅡ,and G-17,and positive rate of Helicobacter pylori IgG antibody(type Ⅰ and type Ⅱ Helicobacter pylori)were analyzed and compared between the two groups.Results The gastric cancer group had significantly lower PGⅠ of(61.73±2.47)μg/L than(76.75±3.46)μg/L in the control group;the gastric cancer group had PG-Ⅱ of(16.57±0.46)μg/L and G-17 of(23.66±1.47)pmol/L,which were higher than(12.89±1.74)μg/L and(11.13±1.74)pmol/L in the control group;the difference was statistically significant(P<0.05).The positive rate of type Ⅰ Helicobacter pylori antibody(50.0％)in the gastric cancer group was higher than 29.8％in the control group,and the difference was statistically significant(P<0.05),but there was no significant difference in the positive rate of type Ⅱ Helicobacter pylori antibody between the two groups(P>0.05).Conclusion The combination of PGⅠ,PGⅡ,G-17 and Helicobacter pylori IgG antibody test for gastric cancer patients can help to improve the diagnostic accuracy,which can provide a scientific basis for the clinical diagnosis of gastric cancer.It is of great significance for the early prevention and treatment of gastric cancer,and is worthy of popularization and application.
关键词
胃蛋白酶原Ⅰ/胃蛋白酶原Ⅱ/胃泌素-17/幽门螺杆菌IgG抗体/胃癌
Key words
Pepsinogen Ⅰ/Pepsinogen Ⅱ/Gastrin-17/Helicobacter pylori IgG antibody/Gastric cancer
维普
万方数据