Expression changes and clinical significance of immune molecule sB7-H3 in patients with rheumatoid arthritis
Objective To explore the expression changes and clinical significance of immune molecule soluble B7-H3(sB7-H3)in patients with rheumatoid arthritis(RA).Methods A total of 78 RA patients were selected as the RA group,and 50 healthy subjects who underwent physical examination during the same period were selected as the control group.Serum levels of sB7-H3,tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)were detected in both groups.The serum levels of sB7-H3,TNF-α and IL-6 were compared between RA group and control group.The serum levels of sB7-H3,TNF-α and IL-6 in patients with different Steinbrocker imaging grading and different RA activity in the RA group were compared,and the correlation of serum sB7-H3 with TNF-α and IL-6 levels in patients with RA was analyzed.Results The serum levels of sB7-H3,TNF-α and IL-6 in RA group were(23.76±3.65)ng/ml,(41.86±11.74)pg/ml and(19.68±10.55)ng/ml,which were significantly higher than(15.47±2.04)ng/ml,(19.72±6.61)pg/ml and(3.65±1.82)ng/ml in the control group(P<0.05).With the elevation of Steinbrocker imaging grading,serum sB7-H3,TNF-α,and IL-6 levels gradually increased in RA patients,and the differences in serum sB7-H3,TNF-α,and IL-6 levels were statistically significant when comparing the levels of patients with different Steinbrocker imaging grading(P<0.05).The serum levels of sB7-H3,TNF-α and IL-6 in RA patients gradually increased with the increase of disease activity,and the serum levels of sB7-H3,TNF-α and IL-6 in patients with different disease activity in RA group had statistical significance(P<0.05).Linear correlation analysis showed that serum sB7-H3 levels were positively correlated with serum TNF-α and IL-6 levels in RA patients(r=0.658,0.517;P=0.000,0.000<0.05).Conclusion Serum sB7-H3 expression is significantly elevated in RA patients,which is closely related to disease activity,and can be used as a marker and potential target for prognosis assessment of RA treatment.
万方数据
维普
