Application of intensity-modulated radiotherapy combined with chemotherapy in hepatocellular carcinoma complicated with venous/inferior vena cava tumor thrombus
Objective To explore the clinical effect of intensity-modulated radiotherapy combined with chemotherapy in hepatocellular carcinoma complicated with venous/inferior vena cava tumor thrombus.Methods A total of 100 patients with liver cancer and venous/inferior vena cava tumor thrombus were selected as study samples and divided into an experimental group and a control group according to random numerical table,with 50 cases in each group.The experimental group was treated with intensity-modulated radiotherapy combined with chemotherapy,and the control group was treated with intensity-modulated radiotherapy.The clinical effects,occurrence of adverse reactions,quality of life scores and psychological state[self-rating anxiety scale(SAS)and self-rating depression scale(SDS)]scores before and after treatment were compared between the two groups.Results The effective rate of the experimental group was 60.00%,which was higher than the control group's 30.00%(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).After treatment,the scores of social function,emotional function,role function and physical function of the experimental group were(90.08±4.21),(91.27±3.16),(91.68±5.23)and(92.89±6.19)points,which were significantly higher than(79.61±3.42),(78.12±6.15),(77.26±6.12)and(78.46±5.13)points in the control group(P<0.05).After treatment,the scores of SDS and SAS in the control group were(51.72±5.51)and(53.01±4.36)points,and those in the experimental group were(40.21±3.53)and(40.01±5.32)points;the experimental group was lower than the control group(P<0.05).Conclusion The application of intensity-modulated radiotherapy combined with chemotherapy has a significant effect on patients with liver cancer complicated with venous/inferior vena cava tumor thrombus.It can not only improve the quality of life of patients,alleviate adverse psychology,but also not increase adverse reactions.it is recommended to be vigorously promoted in the clinic.
Intensity-modulated radiotherapyChemotherapyLiver cancerVeinsInferior vena cavaTumor thrombusQuality of lifeMental stateAdverse reactions
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