Effect of different doses of levothyroxine on early pregnancy with subclinical hypothyroidism and its influence on pregnancy outcome
Objective To explore the effect of different doses of levothyroxine on early pregnancy with subclinical hypothyroidism and its influence on pregnancy outcome.Methods 80 patients with early pregnancy and subclinical hypothyroidism were divided into a low-dose group(32 cases)and a high-dose group(48 cases).All patients were given routine folic acid and dietary guidance after admission,on the basis of which low-dose levothyroxine sodium tablets were given to patients in the low-dose group,and high-dose levothyroxine sodium tablets were given to patients in high-dose group on the basis of conventional treatment and dietary guidance.The treatment effect,thyroid function index level before and after treatment,incidence of adverse reactions and incidence of adverse pregnancy outcome were compared between the two groups.Results The total effective rate was 95.83%in high-dose group,which was higher than 78.13%in low-dose group;the incidence of adverse pregnancy outcome was 4.17%in high-dose group,which was lower than 28.13%in low-dose group(P<0.05).After treatment,the levels of free triiodothyronine(FT3)and free thyroxine(FT4)in high-dose group increased,while the levels of thyroid stimulating hormone(TSH)and thyroid peroxidase antibody(TPOAb)decreased;high-dose group had FT3 of(4.52±1.09)pmol/L and FT4 of(16.45±2.05)pmol/L,which were significantly higher than(2.18±0.74)and(12.29±1.75)pmol/L in low-dose group;high-dose group had TSH of(1.63±0.18)mU/L and TPOAb of(26.19±10.76)IU/ml,which were significantly lower than(1.99±0.15)mU/L and(50.17±15.63)IU/ml in low-dose group(P<0.05).The incidence of adverse reactions in low-dose group was 3.13%,which was significantly lower than 18.75%in high dose group(P<0.05).Conclusion In the clinical treatment of early pregnancy patients with subclinical hypothyroidism,the comprehensive efficacy of different doses of levothyroxine is different,and the specific dosage should be flexibly selected and adjusted according to the patient's condition.
Early pregnancySubclinical hypothyroidismLevothyroxine
万方数据
维普
