Objective To explore the curative effect of pranoprofen eye drops combined with high concentration of sodium hyaluronate eye drops in the treatment of senile dry eye.Methods A total of 96 cases of senile dry eye were randomly divided into a control group and an observation group,with 48 cases in each group.The control group was treated with high concentration(0.3%)of sodium hyaluronate eye drops.On the basis of this,the observation group was treated with pranoprofen eye drops.Patients in both groups were compared in terms of clinical efficacy,various dry eye indicators[tear break-up time(BUT),Schirmer Ⅰ test(SⅠt),corneal fluorescein staining(FL)score],tear inflammatory factors[transforming growth factor-β1(TGF-β1),interleukin-6(IL-6),interleukin-1β(IL-1β)]and symptom(dryness,burning sensation,photophobia,and eye pain)scores.Results The total effective rate of the observation group was 95.83%,which was significantly higher than 75.00%of the control group(P<0.05).After treatment,the observation group had BUT of(5.70±0.69)s and SⅠt of(8.50±1.14)mm/5 min,which were longer than(4.82±0.83)s and(7.26±1.09)mm/5 min in the control group;the observation group had lower FL score of(3.12±0.75)points than(4.31±0.97)points in the control group(P<0.05).After treatment,the observation group had higher TGF-β1 of(79.25±14.91)pg/ml in tears than(65.07±12.68)pg/ml in the control group;the observation group had IL-6 of(252.71±70.48)pg/ml and IL-1β of(75.32±19.57)pg/ml,which were lower than(351.63±79.45)and(99.73±20.94)pg/ml in the control group(P<0.05).After treatment,the symptom scores of dryness,burning sensation,photophobia and eye pain in the observation group were(0.83±0.19),(0.78±0.14),(0.84±0.13)and(0.92±0.15)points,which were significantly lower than(1.48±0.22),(1.41±0.23),(1.45±0.21),(1.49±0.24)points in the control group(P<0.05).Conclusion Pranoprofen eye drops combined with high concentration of sodium hyaluronate eye drops in the treatment of senile dry eye has a significant effect,and can effectively wet the eye surface,prolong BUT,improve tear quality and alleviate clinical symptoms.
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