Efficacy analysis of pranoprofen eye drops combined with high concentration of sodium hyaluronate eye drops in the treatment of senile dry eye
Objective To explore the curative effect of pranoprofen eye drops combined with high concentration of sodium hyaluronate eye drops in the treatment of senile dry eye.Methods A total of 96 cases of senile dry eye were randomly divided into a control group and an observation group,with 48 cases in each group.The control group was treated with high concentration(0.3%)of sodium hyaluronate eye drops.On the basis of this,the observation group was treated with pranoprofen eye drops.Patients in both groups were compared in terms of clinical efficacy,various dry eye indicators[tear break-up time(BUT),Schirmer Ⅰ test(SⅠt),corneal fluorescein staining(FL)score],tear inflammatory factors[transforming growth factor-β1(TGF-β1),interleukin-6(IL-6),interleukin-1β(IL-1β)]and symptom(dryness,burning sensation,photophobia,and eye pain)scores.Results The total effective rate of the observation group was 95.83%,which was significantly higher than 75.00%of the control group(P<0.05).After treatment,the observation group had BUT of(5.70±0.69)s and SⅠt of(8.50±1.14)mm/5 min,which were longer than(4.82±0.83)s and(7.26±1.09)mm/5 min in the control group;the observation group had lower FL score of(3.12±0.75)points than(4.31±0.97)points in the control group(P<0.05).After treatment,the observation group had higher TGF-β1 of(79.25±14.91)pg/ml in tears than(65.07±12.68)pg/ml in the control group;the observation group had IL-6 of(252.71±70.48)pg/ml and IL-1β of(75.32±19.57)pg/ml,which were lower than(351.63±79.45)and(99.73±20.94)pg/ml in the control group(P<0.05).After treatment,the symptom scores of dryness,burning sensation,photophobia and eye pain in the observation group were(0.83±0.19),(0.78±0.14),(0.84±0.13)and(0.92±0.15)points,which were significantly lower than(1.48±0.22),(1.41±0.23),(1.45±0.21),(1.49±0.24)points in the control group(P<0.05).Conclusion Pranoprofen eye drops combined with high concentration of sodium hyaluronate eye drops in the treatment of senile dry eye has a significant effect,and can effectively wet the eye surface,prolong BUT,improve tear quality and alleviate clinical symptoms.
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