Analysis of efficacy of in-hospital preparations of Jiangzhi capsules in the treatment of patients with carotid atherosclerotic plaque and its influence on blood rheology
Objective To analyze the efficacy of in-hospital preparations of Jiangzhi capsules in the treatment of patients with carotid atherosclerotic plaque and its influence on blood rheology.Methods A total of 252 patients with carotid atherosclerotic plaque were selected and divided into an ordinary group and a self-made group according to random numerical table,with 126 cases in each group.The ordinary group was treated with atorvastatin,and the self-made group was treated with in-hospital preparations of Jiangzhi capsules based on the ordinary group.Comparison was made on carotid plaque[plaque volume(PV),carotid intima-media thickness(IMT),and Crouse score],blood lipid indicators[total cholesterol(TC),triglycerides(TG),low-density lipoprotein cholesterol(LDL-C),and high-density lipoprotein cholesterol(HDL-C)],laboratory indicators[hypersensitivity C-reactive protein(hs-CRP),low-density lipoprotein receptor associated protein-6(LRP-6)],and hemorheological parameters between the two groups.Results After medication,the self-made group had PV of(45.33±1.74)mm3,IMT of(1.08±0.13)mm and Crouse score of(4.72±0.36)points,which were lower than(57.26±2.45)mm3,(1.52±0.19)mm and(5.34±0.42)points in the ordinary group(P<0.05).After medication,the self-made group had TC of(3.17±0.42)mmol/L,TG of(1.24±0.27)mmol/L and LDL-C of(1.39±0.20)mmol/L,which were lower than(4.01±0.76),(1.60±0.29)and(2.03±0.35)mmol/L in the ordinary group;the self-made group had significantly higher HDL-C of(1.73±0.25)mmol/L than(1.32±0.13)mmol/L in the ordinary group(P<0.05).After medication,the self-made group had lower hs-CRP of(4.13±0.52)mg/L than(7.58±1.06)mg/L in the ordinary group,and higher LRP-6 of(15.67±2.34)ng/ml than(12.33±2.01)ng/ml in the ordinary group(P<0.05).After medication,the self-made group had whole blood high shear viscosity of(4.72±0.83)mPa·s,whole blood low shear viscosity of(9.02±1.71)mPa·s and plasma viscosity of(1.52±0.18)mPa·s,which were lower than(6.12±1.81),(10.31±1.48)and(1.73±0.16)mPa·s in the ordinary group(P<0.05).Conclusion In-hospital preparation of Jiangzhi capsule has definite curative effect in the treatment of patients with carotid atherosclerotic plaque in clinic,and can significantly improve their hemorheology.
In-hospital preparationsJiangzhi capsulesCarotid atherosclerotic plaqueHemorheologyLipid metabolismLow density lipoprotein receptor-associated protein-6
万方数据
维普
