Observation on the curative effect of Fu-Ke-Zai-Zao Pill on dysmenorrhea of deficiency cold type
Objective To observe the therapeutic effect and safety of Fu-Ke-Zai-Zao Pill on patients with dysmenorrhea of deficiency cold type.Methods A total of 240 patients with dysmenorrhea of deficiency cold type were distributed with digital cards ranging from 1 to 240,with odd number as the observation group and even number as the control group,each with 120 cases.The observation group was treated with Fu-Ke-Zai-Zao Pill and desogestrel and ethinylestradio tablets(trade name:Marvelon),and the control group was treated with Marvelon alone.The efficacy,occurrence of adverse reactions,traditional Chinese medicine syndrome score,pain intensity,serological indexes[prostaglandin E2(PGE2),prostaglandin F2a(PGF2a)]before and after treatment were compared between the two groups.Results The total effective rate of the observation group was 96.67%,which was higher than 81.67%of the control group,and the difference was significant(P<0.05).After treatment,the scores of lower abdominal pain,anal distension,limb chills,and lumbosacral pain in both groups were lower than those before treatment;in the observation group,the scores of lower abdominal pain,anal distension,limb chills and lumbosacral pain were(0.53±0.13),(0.64±0.13),(0.53±0.14)and(0.63±0.21)points,which were lower than(1.32±0.23),(1.64±0.51),(1.12±0.26)and(1.22±0.24)points in the control group;the difference was significant(P<0.05).After treatment,the visual analogue scale(VAS)score and PGF2a in both groups were lower than those before treatment,and PGE2 was higher than that before treatment;the observation group had VAS score of(1.12±0.52)points and PGF2a of(29.03±3.14)pg/ml,which were lower than(2.83±0.57)points and(34.20±3.57)pg/ml in the control group;the observation group had higher PGE2 of(28.57±3.85)pg/ml than(25.24±3.64)pg/ml in the control group;the difference was significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The application of Fu-Ke-Zai-Zao Pill in the treatment of dysmenorrhea of deficiency cold type can promote the improvement of traditional Chinese medicine syndromes and serological indexes,relieve pain,and it is safe and effective.
Fu-Ke-Zai-Zao PillDysmenorrhea of deficiency cold typeTraditional Chinese medicine syndromePainAdverse reactions
万方数据
维普
