Study on clinical effect of vitiligo capsule combined with Qijiao Shengbai capsule on patients with vitiligo
Objective To study the clinical effect of vitiligo capsule combined with Qijiao Shengbai capsule on patients with vitiligo.Methods A total of 200 patients with vitiligo were retrospectively selected and divided into a combined treatment group and a single treatment group according to different medication methods,each with 100 cases.The combined treatment group was treated with vitiligo capsule combined with Qijiao Shengbai capsule,and the single treatment group was treated with vitiligo capsule alone.Both groups were compared in terms of physical signs(lesion site,lesion area,lesion degree)score,blood routine[hemoglobin(Hb),platelet count(PLT),white blood cell count(WBC)],immune function(CD3+,CD4+,CD8+,CD4+/CD8+),laboratory indicators[tumor necrosis factor-α(TNF-α),interferon-γ(IFN-γ),interleukin(IL)-6,IL-8,IL-12,IL-18],and clinical efficacy.Results After the medication,the lesion site score,lesion area score,lesion degree score,Hb,PLT and WBC levels in the combined treatment group were(0.23±0.07)points,(0.24±0.07)points,(0.14±0.04)points,(99.32±11.52)g/L,(179.85±27.56)×109/L and(4.25±0.82)×109/L;in the single treatment group,they were(0.50±0.05)points,(0.48±0.11)points,(0.46±0.06)points,(90.02±10.84)g/L,(150.23±21.65)×109/L and(3.72±0.86)×109/L.After the medication,the lesion site score,lesion area score,lesion degree score,Hb,PLT and WBC levels in both groups were lower than those before the medication;the lesion site score,lesion area score and lesion degree score in the combined treatment group were lower than those in single treatment group,and Hb,PLT and WBC levels were higher than those in single treatment group(P<0.05).After the medication,CD3+,CD4+and CD4+/CD8+in both groups were higher than those before treatment,and the levels of CD8+,TNF-α,IFN-γ,IL-6,IL-8,IL-12 and IL-18 were lower than those before treatment;the levels of CD3+,CD4+and CD4+/CD8+in combined treatment group were higher than those in single treatment group,and the levels of CD8+,TNF-α,IFN-γ,IL-6,IL-8,IL-12 and IL-18 were lower than those in single treatment group(P<0.05).The total effective rate of the combined treatment group was 87.00%(87/100),which was higher than 71.00%(71/100)of the single treatment group(χ2=7.715,P<0.05).Conclusion The clinical effect of vitiligo capsule combined with Qijiao Shengbai capsule on patients with vitiligo is better than that of vitiligo capsule alone.
万方数据
维普
