首页|1例EGFR 20外显子插入突变的非小细胞肺癌的合理用药分析

1例EGFR 20外显子插入突变的非小细胞肺癌的合理用药分析

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为探讨临床上表皮生长因子受体(EGFR)20 外显子插入突变的非小细胞肺癌的用药策略,本研究收集 1 例EGFR 20 外显子插入突变的非小细胞肺癌患者的临床资料,并通过治疗过程监测、文献分析及事后用药分析进行探讨.在本病例中,阿美替尼与奥西替尼均为第三代酪氨酸激酶抑制剂(TKI)药物,将阿美替尼更换为阿法替尼并不是最佳的用药策略.对EGFR 20 外显子插入突变的非小细胞肺癌的患者,化疗方案可以首选培美曲塞+顺铂(PP)方案,靶向药物首选奥西替尼或阿美替尼.
Rational drug use in a case of non-small cell lung cancer with EGFR ex20ins mutation
This paper explores the optimal drug strategy for non-small cell lung cancer with epidermal growth factor receptor(EGFR)ex20ins mutation.The clinical data of a case of non-small cell lung cancer with EGFR ex20ins mutation was collected,and explored it through monitoring the treatment process,literature review and post-medication analysis.In this case,both allmetinib and osimertinib are third-generation tyrosine kinase inhibitors(TKIs),and switching from allmetinib to afatinib is not the best medication strategy.For non-small cell lung cancer with EGFR ex20ins mutation,pemetrexed+cisplatin(PP)regimen can be the best choice for chemotherapy,and osimertinib or Almetinib is the best choice for targeted drugs.

Non-small cell lung cancerEpidermal growth factor receptor ex20ins mutationRational drug use

贺燕、李光灿、庄瑞春、陈芬、黄兴艳

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405400 重庆市开州区人民医院药学部

非小细胞肺癌 表皮生长因子受体20外显子插入突变 合理用药

2024

中国实用医药
中国康复医学会

中国实用医药

影响因子:0.797
ISSN:1673-7555
年,卷(期):2024.19(9)
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