Analysis on the characteristics of human bocavirus infection in hospitalized children with respiratory tract infection in east Guangdong
Objective To analyze the epidemiological characteristics of human bocavirus(HBoV)in hospitalized children with respiratory tract infection in eastern Guangdong,so as to provide data support for the prevention and treatment of HBoV in children in eastern Guangdong.Methods 13499 hospitalized children with respiratory tract infection underwent nucleic acid testing on their throat swab specimens for 16 pathogens,including cytomegalovirus(CMV),Streptococcus pneumoniae(SP),and HBoV.The results of respiratory pathogen detection were observed;the age,year and seasonal distribution of HBoV infection,the detection of HBoV infection and mixed infections,and the clinical manifestations were analyzed.Results Among the 13499 children,269 cases were positive for HBoV,with a positive rate of 1.99%.The positive detection rate of HBoV in preschool children was the highest,at 3.75%(215/5737),followed by infancy(1.13%)and pre-school age(0.19%).No HBoV positivity was detected in school age,and there was a statistically significant difference in comparing the positive detection rate of HBoV in children at different periods(P<0.05).Of the 269 HBoV-positive children,98.51%(265/269)were≤3 years of age,especially those 1-2 years of age accounted for 65.80%(177/269).The positive detection rates of HBoV in spring,summer,fall and winter were 1.65%,1.23%,2.55%and 2.50%,and the differences were statistically significant(P<0.05).HBoV could be detected throughout the year,with predominant prevalence in the fall and winter seasons.The positive detection rates of HBoV were 2.64%,2.26%,1.58%,and 1.63%from April 2019 to March 2020,April 2020 to March 2021,April 2021 to March 2022,and April 2022 to March 2023,with a decreasing trend in the positive detection rate,and the difference in comparison was statistically significant(P<0.05).There were 78 cases of simple HBoV infection,accounting for 29.00%(78/269);191 cases of mixed HBoV infection,accounting for 71.00%(191/269).The clinical characteristics of children with simple infection were cough(78 cases,100.00%),fever(53 cases,67.95%),and wheezing(37 cases,47.44%);the clinical characteristics of children with mixed HBoV infection were cough(190 cases,99.48%),fever(133 cases,69.63%),and wheezing(88 cases,46.07%),and the difference in the clinical characteristics of children with simple and mixed HBoV infection was not statistically significant(P>0.05).Conclusion HBoV is one of the main pathogens of respiratory tract infection in hospitalized children in eastern Guangdong.It is prevalent in autumn and winter,mainly infecting children in infancy,especially children aged 1-2 years.After infection,cough,fever and wheezing often occur.
Respiratory pathogensHuman bocavirusChildrenEpidemiologyClinical features
万方数据
维普
