Study on role of microglia-derived extracellular vesicles in the central nervous system
As the core component of the innate immunity of the central nervous system(CNS),microglia play an important role in the development of the nervous system,the formation of circuits,the activity of neurons and the maintenance of brain homeostasis.Together with the cell synapse,they sense the changes of the surrounding environment and constantly adjust themselves to monitor the brain environment.Extracellular vesicles(EVs)derived from microglia not only reflect the dynamic characteristics of donor cells,but also provide communication carriers for long-distance transmission and targeted regulation of biological activity signals.This paper summarizes the effects of EVs released by microglia under physiological and pathological conditions on neurons,synapses,astrocytes,endothelial cells,cerebral vessels and myelin sheath,as well as their biological functions induced by intracerebral reticular signal transduction,and explores the potential of microglia-derived EVs in the occurrence and treatment of central nervous system diseases,It also provides a certain basis for the functional exploration of glial-derived EVs.
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