Comparison on the efficacy and safety of urokinase and alteplase in the treatment of acute cerebral infarction
Objective To analyze the efficacy and safety of urokinase and alteplase in the treatment of acute cerebral infarction.Methods 80 patients with acute cerebral infarction were divided into a control group and an observation group according to different treatment plans,with 40 cases in each group.The control group received urokinase therapy,and the observation group received alteplase therapy.Comparison was made on clinical efficacy,incidence of complications,National Institutes of Health Stroke Scale(NIHSS),modified Rankin scale(mRS)score and quality of life score before and after treatment,coagulation function before and after thrombolysis between the two groups.Results The total clinical effective rate of the observation group was 97.50%,which was higher than the control group's 82.50%(P＜0.05).After treatment,NIHSS score and mRS score in both groups were lower than those before treatment;the observation group had NIHSS score of(5.52±0.36)points and mRS score of(2.02±0.18)points,which were lower than(7.74±0.51)and(2.75±0.25)points in the control group(P＜0.05).In the observation group,the social functioning score was(73.78±5.84)points,the somatic functioning score was(70.47±5.71)points,the cognitive functioning score was(71.66±5.76)points,and the affective functioning score was(72.79±5.81)points,which were higher than(64.82±5.26),(61.29±5.18),(62.35±5.22),and(63.64±5.24)points in the control group(P＜0.05).The total incidence of complications of the observation group was 5.00%,which was lower than the control group's 22.50%(P＜0.05).Before thrombolysis,there were no differences in prothrombin time(PT),activated partial thromboplastin time(APTT)and thrombin time(TT)levels between two groups(P＞0.05).After 12 h of thrombolysis,PT,APTT and TT in the observation group were(14.41±1.22),(30.42±2.82)and(14.47±1.25)s,which were longer than(11.94±1.03),(27.61±2.33)and(12.08±1.07)s in the control group(P＜0.05).Conclusion Clinical treatment of acute cerebral infarction patients with alteplase can effectively improve coagulation function,nerve defects,greatly improve the quality of life of patients.It has high safety with no obvious complications,and contains a high clinical application value.
万方数据
维普
