Study on the effect of azithromycin combined with budesonide suspension and salbutamol aerosol inhalation in treating pediatric mycoplasma pneumonia
Objective To explore the effect of azithromycin combined with budesonide suspension and salbutamol aerosol inhalation in treating pediatric mycoplasma pneumonia.Methods 130 cases of pediatric mycoplasma pneumonia were divided into a control group and an observation group by random number table method,with 65 cases in each group.The control group was treated with azithromycin alone,and the observation group was treated with budesonide suspension and salbutamol aerosol inhalation on the basis of the control group.Children in both groups were compared in terms of clinical efficacy,time of symptom and sign resolution,length of hospital stay,respiratory function index[airway resistance(Raw),lung dynamic compliance(Cdyn),peak expiratory flow rate(PEF),forced expiratory volume in one second(FEV1)],levels of inflammatory factors[C-reactive protein(CRP),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)],and the incidence of adverse reactions.Results The total effective rate of 96.92%in the observation group was significantly higher than 83.08%in the control group,and the difference was statistically significant(P＜0.05).In the observation group,the time to resolution of cough,pulmonary rale,fever,asthma and the length of hospital stay were(5.33±1.06),(4.10±0.45),(3.10±0.28),(2.41±0.28)and(7.06±0.98)d,which were significantly shorter than(7.82±1.10),(5.40±0.75),(7.12±0.52),(3.56±0.86)and(10.42±1.05)d in the control group.The difference was statistically significant(P＜0.05).After treatment,the observation group had lower Raw of(1.04±0.10)cm H2O/(L·s)(1 cm H2O=0.098 kPa)than(1.25±0.22)cm H2O/(L·s)in the control group;the observation group had Cdyn of(13.32±0.80)ml/cm H2O,PEF of(5.62±0.52)L/s,and FEV1 of(3.55±0.40)L,which were higher than(11.06±0.62)ml/cm H2O,(5.08±0.42)L/s,and(3.20±0.38)L in the control group;the difference was statistically significant(P＜0.05).After treatment,the observation group had CRP of(5.74±0.95)mg/L,TNF-α of(8.16±1.32)pg/ml,and IL-6 of(26.28±2.16)pg/ml,which were lower than(10.08±0.92)mg/L,(14.38±3.05)pg/ml,and(51.33±4.25)pg/ml in the control group,and the difference was statistically significant(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion Azithromycin combined with budesonide suspension and salbutamol aerosol inhalation have significant efficacy and high safety for the treatment of pediatric mycoplasma pneumonia in children.It is conducive to improving the inflammation state and respiratory function,and is worthy of clinical adoption.
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