Study on the effect of Xiaoyao Pill combined with norethisterone in the treatment of patients with menstrual disorder caused by endocrine disorder
Objective To explore the effect of Xiaoyao Pill combined with Norethisterone in the treatment of patients with menstrual disorder caused by endocrine disorder.Methods 88 patients with menstrual disorders caused by endocrine disorders were selected.According to the different admission time of patients,the subjects were divided into a conventional group and an experimental group,with 44 cases in each group.The conventional group was treated with norethisterone alone,and the experimental group was treated with Xiaoyao pill and norethisterone.Both groups were compared in terms of clinical treatment efficiency,traditional Chinese medicine syndrome score,hormone levels,mean menstrual blood volume and quality of life before and after treatment,and the incidence of adverse reactions within 3 months.Results The total effective rate of the experimental group was 97.73%,which was higher than 84.09%of the conventional group(P＜0.05).After treatment,the traditional Chinese medicine syndrome score of(2.00±0.44)points in the experimental group was lower than(3.25±0.71)points in the conventional group(P＜0.05).After treatment,the experimental group had estradiol(E2)of(22.00±2.88)pg/ml,luteinizing hormone(LH)of(25.70±5.69)mIU/ml and follicle stimulating hormone(FSH)of(15.48±6.85)mIU/L,which were lower than(28.35±3.67)pg/ml,(50.74±7.94)mIU/ml and(21.60±3.00)mIU/L in the conventional group;the experimental group had β-endorphin(β-EP)of(42.84±8.16)pg/ml and mean menstrual blood volume of(70.11±10.23)ml,which were higher than(157.22±16.67)pg/ml and(53.77±9.05)ml in the conventional group(P＜0.05).After treatment,the scores of sleep quality,health status,physiological function,social function and mental health in the conventional group were(81.42±7.25),(84.22±6.05),(86.25±5.00),(85.16±5.22)and(85.25±2.16)points,and those in the experimental groups were(90.07±7.14),(91.27±7.27),(92.04±6.32),(90.77±6.61)and(91.06±3.07)points.The scores of sleep quality,health status,physiological function,social function and mental health in the experimental group were higher than those in the conventional group(t=5.6388,4.9444,4.7659,4.4182,10.2669;P=0.0000,0.0000,0.0000,0.0000,0.0000＜0.05).The total incidence of adverse reactions within 3 months after treatment in the experimental group was 2.27%,which was lower than 13.64%in the conventional group(χ2=3.8801,P=0.0489＜0.05).Conclusion For patients with menstrual disorder caused by endocrine disorder,the combined administration of Xiaoyao Pill and norethisterone can improve the symptoms,and has less adverse reactions.it is safer to use,and can improve reproductive hormones,so it is recommended to be applied.
万方数据
维普
