Study on clinical effect of anal fissure resection combined with internal anal sphincterotomy in the treatment of anal fissure patients
Objective To analyze the clinical effect of anal fissure resection combined with internal anal sphincterotomy in the treatment of anal fissure patients.Methods 45 patients who underwent anal fissure surgery were selected as the research subjects.All patients underwent anal fissure resection and internal anal sphincterotomy.Comparison was made on clinical indicators(pain score and swelling score),inflammatory markers[hypersensitive C-reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),interleukin-8(IL-8),interferon-γ(IFN-γ)],and quality of life before and after surgery between the two groups.Results After surgery,the postoperative pain score was(3.32±1.13)points and swelling score was(1.23±0.21)points,which were lower than(5.48±1.14)and(2.87±0.23)points before surgery(P＜0.05).After surgery,patients had hs-CRP of(9.62±1.53)mg/L,TNF-α of(30.23±3.57)pg/ml,IL-6 of(66.35±5.08)ng/L,IL-8 of(32.74±3.17)ng/L,IFN-γ of(54.78±2.01)pg/ml,which were lower than(16.25±2.04)mg/L,(40.15±4.09)pg/ml,(83.37±8.38)ng/L,(45.58±3.45)ng/L,(63.43±3.15)pg/ml before surgery.The difference was statistically significant(P＜0.05).After surgery,the scores of physical function,psychological function,social function and material life were(78.84±2.78),(77.27±2.23),(78.83±2.77)and(77.32±2.26)points,which were higher than(72.13±2.07),(71.19±2.28),(73.19±2.56)and(72.47±2.59)points before surgery,and the difference was statistically significant(P＜0.05).Conclusion In the surgical treatment of anal fissure patients,the use of anal fissure resection combined with internal anal sphincterotomy can reduce postoperative pain and swelling,alleviate inflammatory reactions in the body,and improve patient quality of life,which is worthy of clinical promotion.
万方数据
维普
