Study on the effect of desloratadine citrate disodium in the treatment of chronic sinusitis before endoscopic sinus surgery
Objective To explore the effect of desloratadine citrate disodium in the treatment of chronic sinusitis before endoscopic sinus surgery.Methods 220 patients with chronic sinusitis were selected and divided into a control group and a study group according to random numerical table,with 110 cases in each group.Both groups underwent endoscopic sinus surgery.The study group received desloratadine citrate disodium before surgery,while the control group did not receive desloratadine citrate disodium before surgery.Both groups were compared in terms of efficacy,postoperative complication rate,postoperative recovery time[time of epithelialization of nasal mucosa,restoration of nasal ventilation and hospitalization],indexes of nasal mucociliary clearance function[nasal mucociliary clearance rate,mucociliary clearance rate,and saccharin clearance time],serum inflammatory factors[C-reactive protein(CRP),procalcitonin(PCT),tumor necrosis factor-α(TNF-α)]and quality of life.Results The total effective rate of the study group was 99.09%,which was higher than the control group's 92.73%(P＜0.05).The incidence of postoperative complications was 1.82%in the study group,which was lower than the control group's 9.09%(P＜0.05).The time of epithelialization of nasal mucosa,restoration of nasal ventilation and hospitalization in the study group were(8.03±1.82)weeks,(6.15±1.08)d and(7.09±1.23)d,which were shorter than(10.74±2.31)weeks,(7.69±1.34)d and(9.31±1.89)d in the control group(P＜0.05).After treatment,the nasal mucociliary clearance rate,mucociliary clearance rate,and saccharin clearance time in both groups were significantly improved compared with those before treatment;the study group had nasal mucociliary clearance rate of(7.30±1.28)mm/min and mucociliary clearance rate of(76.39±11.87)%,which were higher than(5.92±1.49)mm/min and(61.18±10.91)%in the control group;the study group had shorter saccharin clearance time of(20.64±4.10)min than(27.35±4.38)min in the control group(P＜0.05).After treatment,the serum CRP,PCT and TNF-α in both groups were significantly decreased compared with those before treatment;the study group had serum CRP of(5.89±1.06)mg/L,PCT of(0.46±0.15)ng/ml and TNF-α of(10.83±2.07)ng/L,which were higher than(7.02±1.27)mg/L,(0.69±0.23)ng/ml and(13.49±2.46)ng/L in the control group(P＜0.05).After treatment,the scores of physiology,psychology,environment and social relations in both groups were significantly higher than those before treatment,and the scores of physiology,psychology,environment and social relations in the study group were higher than those in the control group(P＜0.05).Conclusion The application of desloratadine citrate disodium before endoscopic sinus surgery in chronic sinusitis patients can enhance the curative effect,promote the epithelialization of nasal mucosa as soon as possible,enhance the clearance function of nasal mucosa cilia,reduce the inflammatory reaction of nasal cavity,reduce the postoperative complications,which is beneficial to improve the quality of life of patients.
万方数据
维普
