Analysis of clinical value of NT-proBNP,D-D,CRP detection in middle-aged and elderly patients with acute cerebral infarction
Objective To analyze the diagnostic value of N-terminal pro-B-type natriuretic peptide(NT-proBNP),D-dimer(D-D)and C-reactive protein(CRP)in middle-aged and elderly patients with acute cerebral infarction(ACI).Methods 52 middle-aged and elderly patients with acute cerebral infarction were selected as the observation group[according to diameters of the infarct area,the observation group was divided into large-area infarction group(＞5 cm,10 cases),small-area infarction group(≤5 cm and＞3 cm,16 cases)and medium-area infarction group(≤3 cm and＞1.5 cm,16 cases)],and another 50 healthy subjects were selected as the control group.D-D,CRP and NT-proBNP levels were detected in the observation group and the control group.The levels of CRP,D-D and NT-proBNP in the observation group and the control group were compared,and the levels of CRP,D-D and NT-proBNP in patients with different infarct area in the observation group were compared.Results The levels of CRP,D-D and NT-proBNP in the observation group were higher than those in the control group,and the differences were statistically significant(P＜0.05).In the observation group,the levels of NT-proBNP,D-D and CRP in the large-area infarction group were(3351.70±940.97)pg/ml,(898.43±323.19)ng/ml and(41.79±11.08)mg/L,respectively;the levels of NT-proBNP,D-D and CRP in the medium-area infarction group were(1338.06±345.23)pg/ml,(573.88±312.67)ng/ml and(32.05±11.77)mg/L,respectively;the levels of NT-proBNP,D-D and CRP in small-area infarction group were(447.00±195.72)pg/ml,(334.15±229.81)ng/ml and(18.03±10.14)mg/L,respectively.The levels of NT-proBNP,D-D and CRP in large-area infarction group were higher than those in medium-area infarction group and small-area infarction group;the levels of NT-proBNP,D-D and CRP in medium-area infarction group were higher than those in small-area infarction group;the difference was statistically significant(P＜0.05).Conclusion D-D,CRP and NT-proBNP have high application value in the auxiliary diagnosis of acute cerebral infarction in the middle aged and elderly.
D-dimerC-reactive proteinN-terminal pro-B-type natriuretic peptideAcute cerebral infarctionDiagnostic value
万方数据
维普
