Effect analysis of atorvastatin combined with esmolol on blood lipid metabolism and hemorheology in patients with angina pectoris of coronary heart disease
Objective To observe the effect of atorvastatin combined with esmolol on blood lipid metabolism and hemorheology in patients with angina pectoris.Methods 86 patients with angina pectoris of coronary heart disease were divided into a control group and an observation group according to lottery method,with 43 cases in each group.The control group was treated with atorvastatin,and the observation group was treated with esmolol on the basis of the control group.Both groups were compared in terms of clinical symptom score,lipid metabolism indexes[total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C)],hemorheology indexes(whole blood low shear viscosity,plasma viscosity and fibrinogen),cardiac function indexes(cardiac output,stroke output,left ventricular fraction shortening,left ventricular ejection fraction),and quality of life before and after treatment.Results After treatment,the scores of chest pain,panic,palpitation,chest tightness and dyspnea in the observation group were(1.23±0.45),(1.18±0.54),(1.56±0.82),(1.38±0.52)and(1.07±0.31)points,which were lower than(2.57±0.79),(2.68±0.93),(2.37±0.92),(2.45±0.62)and(2.05±0.46)points in the control group(P＜0.05).After treatment,the observation group had TC of(4.37±0.82)mmol/L,TG of(1.75±0.30)mmol/L and LDL-C of(2.45±0.24)mmol/L,which were lower than(5.56±1.19),(2.96±0.33)and(3.16±0.20)mmol/L in the control group;the observation group had higher HDL-C of(1.51±0.15)mmol/L than(1.26±0.22)mmol/L in the control group(P＜0.05).After treatment,the whole blood low shear viscosity,plasma viscosity and fibrinogen level in the observation group were(7.94±0.80)mPa·s,(5.60±1.17)mPa·s and(4.25±0.46)g/L,which were lower than(9.83±1.06)mPa·s,(6.78±1.32)mPa·s and(4.72±0.12)g/L in the control group(P＜0.05).After treatment,the observation group had stroke output of(53.91±3.40)ml,cardiac output of(4.22±0.61)L/min,left ventricular fraction shortening of(26.01±3.65)%and left ventricular ejection fraction of(50.89±2.62)%,which were higher than(49.56±3.78)ml,(3.59±0.50)L/min,(24.38±2.70)%and(45.71±2.20)%in the control group(P＜0.05).Compared with the control group,the scores of physical function,pain,sleep,social isolation,emotional response and vitality level were lower in the observation group after treatment(P＜0.05).Conclusion The efficacy of atorvastatin combined with esmolol in the treatment of angina pectoris of coronary artery disease is good,and patients'clinical symptoms,lipid metabolism,and hemorheology are all improved,and cardiac function and quality of survival can be improved,which is worthy of application.
万方数据
维普
