Clinical effect evaluation of moxifloxacin combined with cefoperazone sodium and sulbactam sodium in the treatment of severe pneumonia in the elderly
Objective To explore the effectiveness of moxifloxacin combined with cefoperazone sodium and sulbactam sodium in the treatment of severe pneumonia in the elderly.Methods 120 elderly patients with severe pneumonia were selected as observation samples and randomly divided into a control group and an observation group,each with 60 cases.The control group was treated with cefoperazone sodium and sulbactam sodium,and the observation group was treated with moxifloxacin on the basis of the control group.Patients in both groups were compared in terms of arterial blood gas parameters[arterial partial pressure of oxygen(PaO2)and arterial partial pressure of carbon dioxide(PaCO2)],inflammatory factors(C-reactive protein,procalcitonin,white blood cell count),disease recovery time(fever reduction,disappearance of symptoms and signs,leukocyte reduction,obvious absorption of inflammatory lesions,recovery of sputum),and incidence of adverse reactions.Results After treatment,PaO2 increased in both groups,and the observation group had higher PaO2 of(86.37±6.45)mm Hg(1 mm Hg=0.133 kPa)than(80.29±6.21)mm Hg in the control group;PaCO2 decreased in both groups,and the observation group had lower PaCO2 of(42.75±4.42)mm Hg than(48.25±4.63)mm Hg in the control group(P＜0.05).After treatment,the C-reactive protein,procalcitonin and white blood cell counts decreased significantly in both groups;the C-reactive protein,procalcitonin and white blood cell counts in the observation group were(2.18±0.22)mg/L,(1.31±0.11)ng/ml and(7.11±0.57)×109/L,which were lower than(3.79±0.41)mg/L,(2.71±0.26)ng/ml and(11.96±1.12)×109/L in the control group(P＜0.05).After treatment,the time of fever reduction,disappearance of symptoms and signs,leukocyte reduction,obvious absorption of inflammatory lesions,and recovery of sputum in the observation group was shorter than those in the control group(P＜0.05).After treatment,the incidence of adverse reactions in the observation group was 1.67%,which was lower than the control group's 16.67%(P＜0.05).Conclusion For elderly patients with severe pneumonia,moxifloxacin combined with cefoperazone sodium and sulbactam sodium can significantly improve blood gas indexes,reduce inflammatory response,promote disease recovery,and have fewer adverse reactions,which is of significant development value.
Severe pneumoniaMoxifloxacinCefoperazone sodium and sulbactam sodiumInflammatory level
万方数据
维普
