Study on clinical effect of levothyroxin sodium tablets in the treatment of pregnant women with SCH and its influence on TSH,hs-CRP levels and adverse pregnancy outcomes
Objective To explore the clinical effect of levothyroxin sodium tablets in the treatment of pregnant women with subclinical hypothyroidism(SCH)and its influence on thyroid stimulating hormone(TSH),hypersensitive C-reactive protein(hs-CRP)levels and adverse pregnancy outcomes.Methods 130 pregnant patients with SCH were selected and divided into a control group(65 cases)and an observation group(65 cases)according to the numerical random table method.The control group was treated with conventional treatment,and the observation group was treated with conventional treatment and thyroxine.Both groups were compared in terms of therapeutic effects,and the levels of serum hormones[TSH,free triiodothyronine(FT3),free thyroxine(FT4)]and hs-CRP,blood lipid indexes[total cholesterol(TC),triglycerides(TG),low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C)],adverse pregnancy outcomes,and pregnancy complications.Results The total effective rate of the observation group was 96.9%,which was higher than 70.8%of the control group(P＜0.05).Before treatment,there were no differences in TSH,hs-CRP,FT3 and FT4 levels between the two groups(P＞0.05).After treatment,TSH and hs-CRP in both groups were significantly lower than those before treatment,while FT3 and FT4 were higher than those before treatment;the observation group had TSH of(5.34±0.32)mU/L and hs-CRP of(5.21±0.28)mg/L,which were lower than(7.23±1.27)mU/L and(6.89±0.23)mg/L in the control group;the observation group had FT3 of(4.56±0.54)pmol/L and FT4 of(13.68±3.27)pmol/L,which were higher than(3.28±0.27)and(10.28±3.17)pmol/L in the control group(P＜0.05).Before treatment,there were no differences in TG,TC,LDL-C and HDL-C levels between the two groups(P＞0.05).After treatment,the levels of TG,TC,LDL-C and HDL-C in the observation group were(1.31±0.05),(5.06±0.13),(2.46±0.13)and(1.39±0.26)mmol/L,which were better than(2.06±0.11),(5.92±0.26),(3.06±0.16)and(1.24±0.24)mmol/L in the control group(P＜0.05).There were no differences in the rates of postpartum hemorrhage,placental abruption,abortion and preterm delivery between the two groups(P＞0.05).In the observation group,6 cases(9.2%)were combined with fetal abnormality,5 cases(7.7%)were combined with anemia,6 cases(9.2%)were combined with gestational diabetes mellitus,and 3 cases(4.6%)were combined with gestational hypertension.In the control group,18 cases(27.7%)were combined with fetal abnormality,15 cases(23.1%)were combined with anemia,17 cases(26.2%)were combined with gestational diabetes mellitus,and 18 cases(27.7%)were combined with gestational hypertension.The rates of fetal abnormality,anemia,gestational diabetes mellitus and gestational hypertension in the observation group were lower than those in the control group(P＜0.05).Conclusion Levothyroxine sodium tablets in the treatment of pregnant patients with SCH has achieved remarkable effect,which can be used for reference.
万方数据
维普
