Analysis of the therapeutic effect of sacubitril valsartan sodium on patients with coronary heart disease complicated with heart failure
Objective To analyze the effect of sacubitril valsartan sodium on patients with coronary heart disease complicated with heart failure.Methods 84 patients with coronary heart disease and heart failure were divided into a conventional group and a study group by random sampling method,each with 42 cases.The conventional group and the study group were treated with conventional drugs and conventional drugs+sacubitril valsartan sodium.The therapeutic effect,cardiac function index,exercise tolerance,blood pressure,quality of life and serum amino-terminal pro-brain natriuretic peptide and heart-type fatty acid binding protein levels were compared between the two groups.Results The total effective rate of the study group was 97.62%,which was higher than 80.95%of the conventional group,and there was a statistical significance(P<0.05).After treatment,the study group had lower level of brain natriuretic peptide of(210.11±25.13)pg/ml than(246.53±22.87)pg/ml in the conventional group;the study group had left ventricular ejection fraction of(56.92±2.93)%and stroke volume of(52.48±3.37)ml,which were higher than(52.55±2.44)%and(47.43±2.76)ml in the conventional group;the study group had left ventricular end-systolic diameter of(33.65±2.17)mm and left ventricular end-diastolic diameter of(49.61±3.74)mm,which were smaller than(38.98±2.13)and(54.97±3.52)mm in the conventional group;there were statistical significances(P<0.05).The study group had longer 6-min walking distance of(195.98±36.41)m than(165.84±33.65)m in the conventional group;the study group had systolic blood pressure of(115.05±12.11)mm Hg(1 mm Hg=0.133 kPa)and diastolic blood pressure of(84.05±7.21)mm Hg,which were lower than(126.74±12.31)and(90.56±8.78)mm Hg in the conventional group;there were statistical significances(P<0.05).After treatment,the study group had serum amino-terminal pro-brain natriuretic peptide of(422.60±34.01)pg/ml and heart-type fatty acid binding protein of(30.46±9.71)ng/ml,which were lower than(501.39±34.29)pg/ml and(40.25±10.12)ng/ml in the conventional group,and there were statistical significances(P<0.05).The scores of psychological function,physical function,social function and material life and total score in the study group were(95.67±4.21),(91.45±7.38),(95.45±2.56),(90.64±7.37)and(373.21±4.85)points,which were higher than(75.58±7.24),(78.03±7.31),(76.70±6.29),(70.50±6.76)and(300.81±6.85)points in the conventional group.There were statistical significances(P<0.05).Conclusion The use of sacubitril valsartan sodium for the treatment of patients with coronary heart disease complicated with heart failure can improve their cardiac function level,enhance their exercise tolerance,lower their blood pressure level,and has significant therapeutic effects and high clinical application value.
万方数据
维普
