Clinical efficacy of ceftazidime combined with bromhexine hydrochloride in the treatment of chronic obstructive pulmonary disease with pulmonary infection
Objective To analyze the clinical efficacy of ceftazidime combined with bromhexine hydrochloride in the treatment of chronic obstructive pulmonary disease with pulmonary infection,and its impact on lung function and inflammatory factors.Methods 72 patients with chronic obstructive pulmonary disease complicated with pulmonary infection were divided into a treatment group and a control group by envelope drawing method.The control group was treated with ceftazidime,while the treatment group was treated with ceftazidime combined with bromhexine hydrochloride.Patients in both groups were compared in terms of inflammatory factors[procalcitonin(PCT),hypersensitive C-reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)],time of symptom(cough,fever and lung rale)improvement,blood gas indicators[oxygenation index(OI),arterial partial pressure of oxygen(PaO2),arterial partial pressure of carbon dioxide(PaCO2)],lung function indicators[peak expiratory flow(PEF),forced vital capacity(FVC),and forced expiratory volume in one second(FEV1)],and clinical efficacy.Results After treatment,the treatment group had PCT of(0.47±0.19)ng/ml,hs-CRP of(9.28±1.17)mg/L,TNF-α of(5.15±1.86)pg/ml,and IL-6 of(22.16±2.19)pg/ml,which were statistically different from(0.70±0.26)ng/ml,(13.04±1.36)mg/L,(8.28±2.11)pg/ml,and(29.32±3.78)pg/ml in the control group(t=4.285,12.575,6.677,9.834;P<0.05).After treatment,the improvement time of cough,fever and lung rale in the treatment group were(3.94±1.45),(3.08±0.79)and(5.34±1.46)d,which were statistically different from(6.18±2.24),(6.18±1.72)and(7.82±2.17)d in the control group(t=5.037,9.827,5.689;P<0.05).After treatment,the treatment group had OI of(293.49±20.04)mm Hg(1 mm Hg=0.133 kPa)and PaO2 of(86.36±7.72)mm Hg,which were higher than(267.25±15.92)and(78.52±5.57)mm Hg in the control group;the treatment group had lower PaCO2 of(30.12±3.23)mm Hg than(35.49±4.35)mm Hg in the control group.The difference was statistically significant(P<0.05).After treatment,the treatment group had PEF of(5.94±0.58)L/s,FVC of(2.91±0.34)L and FEV1 of(2.31±0.27)L,which were higher than(5.09±0.54)L/s,(2.44±0.31)L and(1.70±0.23)L in the control group.The difference was statistically significant(t=6.436,6.129,10.319;P<0.05).The total clinical effective rate of the treatment group was 94.44%,which was higher than 75.00%of the control group,and the difference was statistically significant(χ2=5.258,P<0.05).Conclusion The combination of ceftazidime and bromhexine hydrochloride in the treatment of chronic obstructive pulmonary disease with pulmonary infection can promote lung function,significantly improve inflammatory factor levels,and enhance clinical efficacy.It is a worthwhile treatment plan to be applied.
万方数据
维普
