Effect analysis of cognitive training combined with repeated transcranial magnetic stimulation on mild cognitive impairment in Parkinson's disease
Objective To explore the effect of cognitive training combined with repeated transcranial magnetic stimulation(rTMS)on mild cognitive impairment in Parkinson's disease(PD-MCI).Methods 57 patients with PD-MCI were randomly divided into an observation group(28 cases)and a control group(29 cases).Both groups of patients received conventional rehabilitation treatment in parkinson's disease(PD),on this basis,the observation group received rTMS+cognitive training,and the control group only received cognitive training.Patients in both groups were compared in terms of Mini-Mental State Examination(MMSE),Montreal Cognitive Assessment Scale(MoCA),Loewenstein Occupational Therapy Cognitive Assessment(LOTCA),Unified Parkinson's Disease Rating Scale(UPDRS-I),d2 attention test scores and the modified Hoehn-Yahr staging before and after treatment.Results After treatment,MMSE score in both groups were higher than that before treatment,and the observation group had higher MMSE score of(27.57±1.26)points than(24.07±1.00)points in the control group(P<0.05).After treatment,MoCA score in both groups was higher than that before treatment,and the observation group had higher MoCA score of(26.32±1.16)points than(20.10±2.06)points in the control group(P<0.05).After treatment,the scores of orientation,visual perception,spatial perception,motor use,visual motor organization and thinking operation in both groups were higher than those before treatment,and the observation group was higher than the control group(P<0.05).After treatment,the d2 attention test score in both groups was higher than that before treatment,and the observation group had higher d2 attention test score of(91.29±2.27)points than(82.83±1.26)points in the control group(P<0.05).After treatment,the UPDRS-Ⅰscore in both groups was lower than that before treatment,and the observation group had lower UPDRS-Ⅰ score of(4.64±0.83)points than(6.72±0.80)points in the control group(P<0.05).Before and after treatment,there was no significant difference in the modified Hoehn-Yahr staging between and within the two groups(P>0.05).Conclusion Cognitive training combined with rTMS can significantly improve the cognitive function in patients with PD-MCI,but the combined effect of the two is better than that of a single treatment.
Parkinson's diseaseMild cognitive impairmentCognitive trainingRepeated transcranial magnetic stimulationCognitive function
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