Analysis of the effect of high flow hemofiltration in the treatment of septic shock complicated with acute kidney injury in ICU
Objective To analyze the clinical effect of high flow hemofiltration in the treatment of septic shock complicated with acute kidney injury in intensive care unit(ICU).Methods 96 patients with septic shock and acute kidney injury in ICU were randomly divided into an observation group and a control group,with 48 patients in each group.The control group was given renal replacement therapy,and the observation group was given high flow hemofiltration.The infusion volume,norepinephrine use,renal tubular injury,and satisfaction scores of patients and their families of the two groups were observed and compared.Results At 12,24,and 36 h after the start of hemofiltration,the infusion volume and norepinephrine use in the observation group were(36.21±13.23),(51.11±16.65),(45.27±9.19)g/(kg·min),and(1.19±0.21),(1.03±0.21),(0.35±0.27)μg/(kg·min),and those in the control group were(95.08±12.26),(102.34±13.79),(108.34±16.16)g/(kg·min)and(1.39±0.28),(1.31±0.11),(1.28±0.45)μg/(kg·min).At 12,24,and 36 h after the start of hemofiltration,the infusion volume and norepinephrine use in the observation group were significantly lower than those in the control group,and there was statistical significance(P<0.05).The renal tubule injury in the observation group was better than that in the control group,and there was statistical significance(P<0.05).The scores of daily behavior,control behavior,processing behavior and monitoring behavior and total scores of patients and their families in the observation group were(24.3±4.5),(31.4±4.8),(19.6±3.6),(12.5±3.8)and(87.8±10.8)points,which were higher than(15.1±3.2),(16.0±5.9),(11.2±2.7),(6.3±2.1)and(48.6±8.9)points in the control group,and there was statistical significance(P<0.05).Conclusion The application of high flow hemofiltration in the treatment of septic shock patients with acute kidney injury in ICU has significant effects,which is conducive to reducing the infusion volume,the use of norepinephrine and the degree of renal tubule injury,and has positive significance for maintaining a good doctor-patient relationship,which is worthy of future promotion.
High flow hemofiltrationIntensive care unitInfectious shockAcute renal injury
万方数据
维普
