Study on the diagnostic value of peripheral blood SII,NLR and PLR for colorectal cancer and its correlation with prognosis
Objective To explore the diagnostic value of peripheral blood systemic immune-inflammation index(SII),neutrophil-to-lymphocyte ratio(NLR)and platelet to lymphocyte ratio(PLR)for colorectal cancer and its correlation with prognosis.Methods A total of 150 cases of colorectal cancer patients(colorectal cancer group),and 150 healthy individuals(the control group)were selected for study,and the clinical data of the two groups was retrospectively analyzed.The preoperative levels of SII,NLR and PLR in peripheral blood of the two groups were detected and compared.The diagnostic efficiency of SII,NLR and PLR in colorectal cancer patients was analyzed by receiver operating characteristic(ROC)curve,and the clinicopathological characteristics of patients with different levels of SII and NLR in peripheral blood of colorectal cancer group were analyzed.Results The levels of NLR,SII and PLR in colorectal cancer group were(3.17±1.46),(912.49±749.34)and(318.41±319.02),which were higher than(1.93±0.38),(406.37±193.2)and(41.37±51.36)in control group.The difference was statistically significant(P<0.05).The area under the curve(AUC)of SII,NLR and PLR alone and SII+NLR+PLR combined diagnosis of colorectal cancer were 0.785,0.837,0.847 and 0.872,the sensitivity were 63.28%,65.31%,77.91%and 87.40%,and the specificity were 86.42%,85.43%,80.0%and 77.90%.The pathological tissue types and lymph node metastasis were compared between low SII group and high SII group,and between low NLR group and high NLR group,and the difference was statistically significant(P<0.05).There was no significant difference in age between low SII group and high SII group,and between low NLR group and high NLR group(P>0.05).Conclusion SII,NLR,and PLR are predictive indicators for colorectal cancer,and the combined diagnosis of the three is of higher value;high SII and high PLR are risk factors for lymph node metastasis of colorectal cancer,and have certain clinical guiding significance.
Peripheral bloodSystemic immune-inflammation indexNeutrophil-to-lymphocyte ratioPlatelet to lymphocyte ratioColorectal cancer
万方数据
维普
