Predictive value of endometriosis fertility index combined with serum AMH for natural pregnancy outcome in patients with endometriosis
Objective To explore the predictive value of endometriosis fertility index(EFI)combined with serum anti-Müllerian hormone(AMH)for natural pregnancy outcome in patients with endometriosis(EMT).Methods 113 patients with endometriosis who underwent laparoscopic surgery were selected for the study,and all of them were tested for EFI and AMH before and after surgery,and then followed up for 2 years,and they were divided into successful natural pregnancy group(70 cases)and failed natural pregnancy group(43 cases)according to their natural pregnancy outcome.Postoperative EFI score and preoperative and postoperative AMH levels were counted in 113 patients.The general data and postoperative EFI score and AMH levels were compared between the successful natural pregnancy group and the failed natural pregnancy group;the predictive value of EFI and AMH alone and in combination on the outcome of natural pregnancy in patients with endometriosis was analyzed.Results The postoperative EFI score of 113 patients with endometriosis was(5.63±1.38)points;the preoperative AMH level was(2.30±0.64)ng/ml,and the postoperative level was(4.16±0.59)ng/ml,and the level of AMH postoperatively was higher than that preoperatively(P<0.05).After 2 years of follow-up,70 patients had successful natural pregnancies(natural pregnancy success group),with a success rate of 61.95%,and 43 had failed natural pregnancies(failed natural pregnancy group),with a failure rate of 38.05%.There was no significant difference in age,course of infertility,body mass index,and type of infertility between the two groups(P>0.05).Postoperatively,the successful natural pregnancy group had EFI score of(6.03±0.72)points and AMH level of(4.32±0.55)ng/ml,which were higher than(4.33±1.26)points and(3.89±0.87)ng/ml in failed natural pregnancy group(P<0.05).The area under the curve(AUC)of the combined test was 0.902 and the specificity was 97.33%,which were higher than EFI and AMH test alone(0.816,90.54%and 0.802,93.45%).Conclusion After laparoscopic surgery for endometriosis patients,the success rate of natural pregnancy is higher in those with higher EFI and AMH levels.EFI and AMH can predict the outcome of natural pregnancy,and the predictive value of the combination of both is higher.
万方数据
维普
