Effect of ceftazidime-avibactam in acute respiratory distress syndrome patients with Pseudomonas aeruginosa respiratory infection
Objective To explore the effect of ceftazidime-avibactam(CAZ-AVI)in acute respiratory distress syndrome(ARDS)patients with Pseudomonas aeruginosa respiratory infection.Methods 60 patients with acute respiratory distress syndrome complicated with Pseudomonas aeruginosa respiratory tract infection were selected as research subjects,and were divided into a control group and an experimental group by random number table method,with 30 cases in each group.The control group received basic treatment,and the experimental group was treated with ceftazidime-avibactam on the basis of the control group.The clinical efficacy,bacterial clearance and serum levels of interleukin-6 and IL-8 before and after treatment were compared between the two groups.Results The experimental group had total effective rate of 93.33%and bacterial clearance rate of 90.00%,which were higher than 73.33%and 66.67%in the control group(P<0.05).After treatment,the serum IL-6 and IL-8 levels in both groups were lower than those before treatment;the experimental group had IL-6 of(29.53±6.33)pg/ml and IL-8 of(3.38±0.69)pg/ml,which were lower than(34.09±9.84)and(4.01±0.85)pg/ml in the control group(P<0.05).Conclusion In patients with acute respiratory distress syndrome complicated with Pseudomonas aeruginosa respiratory infection,the treatment of ceftazidime-avibactam can promote the elimination of bacteria and inflammatory factors in the patients,and promote the improvement of clinical efficacy,which is worthy of clinical application.
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