Clinical study of carbetocin in preventing postpartum hemorrhage in vaginal delivery
Objective To analyze the clinical effect of carbetocin in preventing postpartum hemorrhage in vaginal delivery.Methods 98 cases of women with a tendency to postpartum hemorrhage were divided into a study group and a control group by random numerical table method,with 49 cases in each group.The control group was given oxytocin to prevent postpartum hemorrhage,and the study group was given carbetocin on the basis of the control group to prevent postpartum hemorrhage.Comparison was made on amount of vaginal bleeding at different times after delivery,hemoglobin and heart rate before and after delivery,the occurrence of postpartum hemorrhage,the level of inflammatory factors before and after medication,and the occurrence of adverse reactions between the two groups.Results The amount of vaginal bleeding at 2 and 24 h postpartum in the study group were(169.87±18.16)and(199.38±21.46)ml,which were significantly lower than(263.75±27.93)and(292.09±28.15)ml in the control group,and the difference was significant(P<0.05).After delivery,the study group had higher hemoglobin of(111.02±1.16)g/L than(109.08±0.96)g/L in the control group,and lower heart rate of(74.89±5.83)beats/min than(81.92±7.11)beats/min in the control group.The difference was significant(P<0.05).The incidence of postpartum hemorrhage(6.12%)in the study group was significantly lower than that in the control group(20.41%),and the difference was significant(P<0.05).After medication,the study group had IL-10 of(28.10±2.32)ng/ml and IL-2 of(27.34±1.65)ng/ml,which were lower than(36.25±3.56)and(32.44±2.14)ng/ml in the control group,and the difference was significant(P<0.05).The total incidence of adverse reactions in the study group(2.04%)was significantly lower than that in the control group(12.24%),and the difference was significant(P<0.05).Conclusion Carbetocin is effective in preventing postpartum hemorrhage in vaginal delivery,and it is long-lasting and has a high safety profile.
万方数据
维普
