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误诊肺细支气管腺瘤2例分析

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肺细支气管腺瘤(BA)2 例,患者无任何临床症状,肺部体检CT发现左肺实性结节及磨玻璃结节各 1 例,影像及冰冻病理诊断为肺腺癌,完善相关检查后行胸腔镜下左肺楔形切除,术后病理均为左肺细支气管腺瘤.术后未进行特殊治疗,分别随访至术后 4 年左右,患者情况良好,未出现肿瘤远处转移或复发迹象.细支气管腺瘤新近被提出的来源于细支气管黏膜上皮的一种良性肿瘤.通常在计算机断层扫描中偶然在周围肺野中发现.在 2021 年最新分类的第 5 版世界卫生组织胸部肿瘤,新增了细支气管腺瘤/纤毛黏液结节性乳头状瘤(CMPT)疾病,并明确表明此肿瘤是良性肿瘤.细支气管腺瘤的组织学变异可分为"经典"CMPT(近端型)和"非经典"CMPT(远端型).病理典型特征为肺实质内结节,边界清晰,无包膜,呈乳头状或肺泡贴壁生长,含有连续的基底细胞层和(或)纤毛细胞、黏液细胞、Ⅱ型肺泡上皮细胞、肺泡细胞的腔面细胞构成,由于该肿瘤发病罕见,国内报道较少,其临床、放射学和病理学表现可能模仿各种良性和恶性过程.临床医生缺乏认识,极易误诊为腺癌,现将本院 2 例细支气管腺瘤误诊病例报告如下.
Analysis of 2 cases of misdiagnosis of pulmonary bronchial adenoma
There were 2 cases of bronchial adenoma of the lung without any clinical symptoms.CT examination of the lung revealed 1 case of solid nodules and 1 case of ground glass nodules of the left lung,which were diagnosed as adenocarcinoma of the lung by imaging and freezing pathology.After completing relevant examinations,thoracoscopic wedges of the left lung were performed,and the postoperative pathology was all left lung bronchial adenoma.No special treatment was given after the operation,and the patients were followed up to about 4 years after the operation.The patients were in good condition with no signs of distant metastasis or recurrence of the tumor.Bronchial adenoma is a newly proposed benign tumor originating from the bronchial mucosal epithelium.It is usually found by chance in the surrounding pulmonary field during computed tomography.In the 5th edition of the World Health Organization's latest classification of thoracic tumors in 2021,a new BA/ciliated multinodular papilloma tumor(CMPT)is added and the tumor is clearly labeled as benign.The histological variation of bronchial adenoma can be divided into"classical"CMPT(proximal type)and"non-classical"CMPT(distal type).The typical pathological features are nodules in the lung parenchyma with clear boundaries,no envelope,papillary or alveolar adherent growth,consisting of continuous basal cell layer and/or ciliated cells,mucous cells,type Ⅱ alveolar epithelial cells,and alveolar surface cells.Due to the rare incidence of this tumor,few reports have been reported in China.Their clinical,radiological and pathological manifestations may mimic a variety of benign and malignant processes.The lack of understanding of clinicians makes it easy to be misdiagnosed as adenocarcinoma.2 misdiagnosed cases of bronchial adenoma in our hospital are reported as follows.

Bronchial adenomaLung CTPulmonary nodule

张胜波、张言敏、张纪银、范作兰

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261500 山东省高密市人民医院影像中心

261500 山东省高密市人民医院病理科

261500 山东省高密市人民医院胸心血管外科

261500 山东省高密市市立医院呼吸内科

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细支气管腺瘤 肺部CT 肺结节

2024

中国实用医药
中国康复医学会

中国实用医药

影响因子:0.797
ISSN:1673-7555
年,卷(期):2024.19(11)
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