Analysis of the effect of oxytocin combined with carboprost suppositories in the prevention of postpartum hemorrhage after trial of vaginal delivery in high-risk parturients
Objective To explore the effect of oxytocin combined with carboprost suppositories in the prevention of postpartum hemorrhage after trial of vaginal delivery in high-risk parturients.Methods 70 high-risk parturients undergoing trial of vaginal delivery were selected.A random number table method was used to divide them into a control group and a study group,with 35 cases in each group.The control group was treated with oxytocin,while the study group was treated with oxytocin combined with carboplatin suppositories.Comparison was made on the duration of labor,amount of postpartum bleeding,occurrence of postpartum bleeding,coagulation index[thrombin time(TT),prothrombin time(PT),activated partial thromboplastin time(APTT)],blood routine index and psychological score between the two groups.Results There was no significant difference in the duration of the first and second stages of labor between the two groups(P>0.05).The duration of the third stage of labor in the study group was(8.34±1.18)min,which was shorter than(10.92±1.54)min in the control group(P<0.05).The amount of postpartum bleeding at 2 and 24 h postpartum were(336.43±65.74)and(513.16±49.07)ml,which were lower than(389.81±58.92)and(493.49±72.34)ml in the control group;the study group had incidence of postpartum hemorrhage of 2.86%,which was lower than 17.14%in the control group(P<0.05).After intervention,TT,PT and APTT in both groups were significantly longer than those before intervention,but TT,PT and APTT in the study group were shorter than those in the control group(P<0.05).After intervention,the hemoglobin and red blood cell count in both groups were significantly reduced compared with those before intervention;however,the study group had hemoglobin of(121.53±3.41)g/L and red blood cell count of(3.79±0.45)×1012/L,which were higher than(116.85±3.28)g/L and(3.28±0.39)×1012/L in the control group(P<0.05).After intervention,the scores of anxiety and depression in both groups were significantly lower than those before intervention,and the scores of anxiety and depression in the study group were lower than those in the control group(P<0.05).Conclusion The combination of oxytocin and carboprost suppository can accelerate the progress of the third stage of labor,effectively prevent and treat postpartum hemorrhage,and reduce the influence on coagulation function and blood routine indexes,which is conducive to reducing postpartum negative emotions.
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