Clinical effect of halometasone cream combined with 308 nm excimer laser in treatment of alopecia areata
Objective To explore the clinical effect of halometasone cream combined with 308 nm excimer laser in treatment of alopecia areata.Methods 100 patients with alopecia areata were retrospectively selected and divided into combined treatment group(308 nm excimer laser combined with halometasone cream treatment)and single treatment group(halometasone cream alone treatment)according to different treatment methods,with 50 cases in each group.The clinical efficacy,serum inflammatory factor[interleukin(IL)-6,IL-10,IL-12,leukotriene B4(LTB4),leukotriene C4(LTC4),C-reactive protein(CRP)]levels,occurrence of adverse reactions and recurrence were compared between the two groups.Results The total effective rate of the combined treatment group was 92.00%(46/50),which was higher than the single treatment group's 60.00%(30/50)(x2=14.035,P=0.000<0.05).After treatment,the serum levels of IL-6,IL-10,IL-12,LTB4,LTC4 and CRP in both groups were lower than those before treatment;the combined treatment group had IL-6 of(0.41±0.12)ng/L,IL-10 of(2.00±0.35)μg/L,IL-12 of(63.15±11.15)ng/L,LTB4 of(2.10±0.31)μg/L,LTC4 of(2.00±0.36)μg/L and CRP of(1.80±0.30)mg/L,which were lower than(0.46±0.11)ng/L,(2.42±0.45)μg/L,(71.66±15.08)ng/L,(2.55±0.41)μg/L,(2.48±0.40)μg/L and(2.22±0.28)mg/L in the single treatment group(P<0.05).The incidence of adverse reactions in the combined treatment group was 8.00%(4/50),which was lower than the single treatment group's 22.00%(11/50)(x2=3.843,P=0.049<0.05).The recurrence rate in the combined treatment group was 2.00%(1/50),which was lower than the single treatment group's 18.00%(9/50)(x2=7.111,P=0.008<0.05).Conclusion The clinical effect of 308 nm excimer laser combined with halometasone cream in the treatment of alopecia areata is more significant than that of halometasone cream alone.
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