Study on the correlation of chemokines MCP-1 and RANTES with unexplained recurrent spontaneous abortion
Objective To analyze the risk factors of unexplained recurrent spontaneous abortion(URSA),and observe the correlation of chemokines monocyte chemotactic protein-1(MCP-1)and regulated upon activation normal T cell expressed and secreted(RANTES)with unexplained recurrent spontaneous abortion(URSA).Methods 70 patients with URSA were selected as the URSA group,and another 70 pregnant women with normal pregnancy in the same period were selected as the normal pregnancy group.The clinical data of the two groups were compared,including age,gravidity and parity,family genetic history,history of smoking and drinking,body mass index(BMI),occupation,and education level,etc.The levels of RANTES and MCP-1 in the serum of the two groups were detected by enzyme-linked immunosorbent assay(ELISA).The risk factors for the occurrence of URSA were analyzed.Comparison was made on serum MCP-1 and RANTES levels between the two groups,and the serum MCP-1 and RANTES levels of patients with different gestational ages and number of abortions in the URSA group.Results Univariate analysis showed that≥35 years of age,BMI≥24 kg/m2,smoking history,drinking history,junior high school education or below accounted for 62.9%,67.1%,61.4%,57.1%and 65.7%in URSA group,which were higher than 30.0%,27.1%,18.6%,17.1%and 37.1%in the normal pregnancy group(P<0.05).Multivariate Logistic regression analysis showed that BMI≥24 kg/m2,≥35 years of age,history of smoking and drinking,and education level of junior high school or below were the risk factors for URSA(OR>1,P<0.05).The serum levels of MCP-1 and RANTES in URSA group were(127.31±70.12)and(220.98±69.51)ng/L,which were lower than(239.20±75.64)and(412.34±82.47)ng/L in normal pregnancy group(P<0.05).In URSA group,the serum levels of MCP-1 and RANTES decreased with the increase of abortion times,and the difference was statistically significant(P<0.05).In URSA group,there was no significant difference in serum MCP-1 and RANTES levels among patients of different gestational ages(P>0.05).Conclusion High BMI,older age,history of smoking and drinking,and low education level are risk factors for URSA,and the abnormal expression of serum RANTES and MCP-1 is closely related to the occurrence of URSA.In patients with URSA,timely detection of serum RANTES and MCP-1 levels in early pregnancy may be a clinical indicator of URSA embryo loss and the effect of immunotherapy.
AbortionHabitualChemokineMonocyte chemotactic protein-1Regulated upon activation normal T cell expressed and secreted
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