Effect analysis of clopidogrel combined with low molecular weight heparin calcium in the treatment of progressive ischemic stroke
Objective To explore the effect of clopidogrel combined with low molecular weight heparin calcium in the treatment of progressive ischemic stroke.Methods A total of 100 patients with progressive ischemic stroke were divided into a control group(low molecular weight heparin calcium)and an observation group(clopidogrel combined with low molecular weight heparin calcium)according to the differentiated treatment plan,with 50 cases in each group.The National Institutes of Health Stroke Scale(NHISS)score,blood rheology indices,quality of life levels,clinical outcomes and safety were compared between the two groups.Results After treatment,NIHSS score in both groups was significantly lower than that before treatment,and the observation group had lower NIHSS score of(9.33±2.89)points than(12.42±3.11)points in the control group.The difference was significant(P<0.05).After treatment,the fibrinogen,plasma viscosity and platelet aggregation rate in both groups were significantly decreased compared with those before treatment;the observation group had fibrinogen of(2.12±0.43)g/L,plasma viscosity of(1.09±0.27)mPa·s and platelet aggregation rate of(34.46±15.62)%,which were lower than(2.73±0.55)g/L,(1.31±0.34)mPa·s and(51.22±20.31)%in the control group;the difference was significant(P<0.05).After treatment,the scores of physiological dimension,psychological dimension,social function dimension and substance level dimension in both groups were higher than those before treatment,and the observation group was significantly higher than the control group.The difference was significant(P<0.05).The total clinical effective rate of the observation group was 96.00%(48/50),which was higher than 82.00%(41/50)of the control group,and the difference was significant(P<0.05).The incidence of adverse reactions in the observation group was 6.00%,which was lower than 20.00%in the control group,and the difference was significant(P<0.05).Conclusion For patients with progressive ischemic stroke,the combination therapy of clopidogrel and low molecular weight heparin calcium has achieved remarkable results in improving blood rheology indices,neurological deficits and reducing toxic side effects compared with monotherapy,and the quality of life has also been significantly improved,which is worthy of active clinical promotion and application.
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