Effects of ginkgo ketone ester dispersible tablets on carotid plaque area,hemorheology and inflammation level in secondary prevention of cerebral infarction
Objective To observe the effect of ginkgo ketone ester dispersible tablets(trade name:Yinxinke)on carotid plaque area,hemorheology and inflammation level in secondary prevention of cerebral infarction.Methods 80 patients with acute cerebral infarction were selected as the study subjects,and were divided into western medicine group(37 cases)and Yinxinke group(43 cases)by single and double number labeling method.During the study,1 case was lost to follow-up in the western medicine group,2 cases was lost to follow-up in the Yinxinke group,resulting in 36 cases in the western medicine group and 41 cases in the Yinxinke group.Patients in the western medicine group were treated with oral aspirin or clopidogrel combined with atorvastatin,while patients in the Yinxinke group were treated with ginkgo ketoester dispersible tablets on the basis of the western medicine group.Both groups were compared in terms of difference in hemorheology[whole blood low shear viscosity,whole blood high shear viscosity,plasma viscosity,erythrocyte sedimentation rate(ESR),fibrinogen(FIB),platelet aggregation rate],carotid plaque[carotid plaque area,carotid intima-media thickness(IMT),carotid artery stenosis rate],cystatin C(Cys-C),retinol binding protein(RBP),hypersensitive C-reactive protein(hs-CRP)before and after 6 months of treatment,and occurrence of clinical events within 1-year follow-up.Results Compared with before treatment,the whole blood low shear viscosity,whole blood high shear viscosity,plasma viscosity,ESR,FIB and platelet aggregation rate were decreased in both groups after treatment,and Yinxinke group was lower than western medicine group(P<0.05).Compared with before treatment,IMT,carotid plaque area and carotid stenosis rate decreased in both groups after treatment;Yinxinke group had IMT of(0.87±0.10)mm,carotid plaque area of(11.14±1.56)mm2 and carotid artery stenosis rate of(31.56±4.23)%,which were lower than(0.93±0.15)mm,(13.44±2.02)mm2 and(36.85±5.02)%in western medicine group(P<0.05).Compared with before treatment,hs-CRP,RBP and Cys-C decreased in both groups after treatment;Yinxinke group had hs-CRP of(7.78±2.15)mg/L,RBP of(41.32±6.77)mg/L and Cys-C of(0.95±0.21)mg/L,which were lower than(10.14±2.74),(50.26±8.17)and(1.12±0.38)mg/L in western medicine group(P<0.05).The recurrence rate of cerebral infarction in Yinxinke group was 4.88%(2/41),which was lower than 22.22%(8/36)in western medicine group(P<0.05).There was no significant difference in the incidence of symptomatic gastrointestinal hemorrhage,cerebral hemorrhage,acute myocardial infarction,heart failure,malignant arrhythmia and cardiac death between the two groups within 1 year of follow-up(P>0.05).Conclusion Ginkgo ketone ester dispersible tablets for secondary prevention of cerebral infarction can reduce the area of carotid plaque and the recurrence rate of cerebral infarction,which may be related to improving hemorheology and inhibiting inflammatory reaction.
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