Analysis of the practical effect of modified TAC regimen in the neoadjuvant chemotherapy of HER-2 negative breast cancer
Objective To analyze the practical effect of modified TAC regimen(doxorubicin hydrochloride liposome combined with albumin-bound paclitaxel and cyclophosphamide)in the neoadjuvant chemotherapy of human epidermal growth factor receptor 2(HER-2)negative breast cancer.Methods 80 patients with HER-2 negative breast cancer who received neoadjuvant chemotherapy were selected and randomly divided into an observation group and a control group,with 40 cases in each group.The observation group was treated with modified TAC regimen,while the control group was treated with epirubicin,docetaxel and cyclophosphamide chemotherapy.Both groups were compared in terms of the clinical efficacy,incidence of adverse reactions to chemotherapy,quality of life,myocardial enzyme spectrum related indicators[creatine kinase isoenzyme(CK-MB),creatine kinase(CK),cardiac troponin I(cTnI)],left ventricular ejection fraction(LVEF),and serum tumor markers[carbohydrate antigen(CA)15-3,CA19-9,and carcinoembryonic antigen(CEA)]levels before and after treatment.Results The observation group had total effective rate of 82.50%and complete response(CR)rate of 27.50%,which were significantly higher than 60.00%and 10.00%in the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of CA15-3,CA19-9 and CEA in the observation group were(7.83±1.37)U/ml,(10.20±1.36)U/ml and(1.18±0.27)ng/ml,which were significantly lower than(16.28±1.04)U/ml,(16.28±1.04)U/ml and(2.65±0.95)ng/ml in the control group,and the difference was statistically significant(P<0.05).After treatment,the observation group had higher LVEF of(62.43±4.37)%than(57.28±5.46)%in the control group;the observation group had CK-MB of(20.58±2.36)U/L,cTnI of(33.92±6.37)μg/ml and CK of(122.07±20.45)U/L,which were lower than(32.18±3.03)U/L,(42.78±8.25)μg/ml and(137.57±27.69)U/L in the control group;the difference was statistically significant(P<0.05).The incidence of cardiotoxicity and gastrointestinal reactions in the observation group were 7.50%and 25.00%,which were lower than 32.50%and 47.50%in the control group,and the difference was statistically significant(P<0.05).The scores of social function,role function,emotional function and physical function after chemotherapy in the observation group were(77.28±3.18),(78.18±4.27),(76.94±5.11)and(77.87±4.13)points,which were significantly higher than(64.14±2.29),(65.35±2.96),(65.72±2.58)and(66.03±3.29)points in the control group,and the difference was statistically significant(P<0.05).Conclusion Modified TAC regimen in the neoadjuvant chemotherapy of HER-2 negative breast cancer can improve the clinical effect,reduce the incidence of chemotherapy reactions such as cardiotoxicity,and significantly improve the quality of life of patients.It is worthy of promotion.
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