Observation on the curative effect of Tongqiao Erlong pill in the treatment of acute otitis media
Objective To observe the curative effect and safety of Tongqiao Erlong pill in the treatment of acute otitis media.Methods A total of 120 patients with acute otitis media were selected and divided into an observation group and a control group according to random number table method,with 60 cases in each group.The control group was treated with Western medicine,including oral amoxicillin and clavulanate potassium,and levofloxacin combined with dexamethasone ear bath.The observation group was given Tongqiao Erlong pill on the basis of the control group.Patients in both groups were compared in terms of efficacy,symptom score,serum inflammatory factors[interleukin-2(IL-2),interleukin-4(IL-4),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),procalcitonin(PCT),platelet activating factor(PAF)]before and after treatment,and the occurrence of adverse reactions.Results The total effective rate of the observation group was 96.67%,which was higher than 85.00%of the control group,and there was significant difference between groups(P<0.05).After treatment,the scores of deafness(hearing loss),tinnitus,earache,aural fullness,tympanic congestion and tympanic effusion in both groups were significantly decreased compared with those before treatment;the scores of deafness(hearing loss),tinnitus,earache,aural fullness,tympanic congestion and tympanic effusion in the observation group were(0.51±0.27),(0.09±0.03),(0.19±0.05),(0.10±0.03),(0.28±0.07)and(0.36±0.09)points,which were lower than(0.77±0.22),(0.12±0.06),(0.27±0.14),(0.12±0.06),(0.35±0.09)and(0.56±0.07)points in the control group;there was significant difference between groups(P<0.05).After treatment,the levels of IL-2,IL-4,IL-6,TNF-α,PCT and PAF were significantly decreased in both groups;in the observation group,IL-2,IL-4,IL-6,TNF-α,PCT and PAF were(3.02±0.17)ng/L,(3.52±0.45)ng/L,(2.32±0.28)ng/L,(23.88±3.02)pg/ml,(1.84±0.31)ng/ml and(100.21±13.96)μg/L,which were lower than(3.99±0.32)ng/L,(4.73±0.56)ng/L,(3.13±0.19)ng/L,(55.31±5.33)pg/ml,(3.33±0.55)ng/ml and(131.62±15.23)μg/L in the control group;there was significant difference between groups(P<0.05).There was no difference in the incidence of adverse reactions between the two groups(χ2=2.034,P=0.154>0.05).Conclusion Tongqiao Erlong pill combined with conventional western medicine has good efficacy and safety in the treatment of acute otitis media,and is worthy of clinical promotion.
NETL
NSTL
万方数据
