Efficacy observation of Danshen injection in preventing lower limb deep vein thrombosis in patients after general surgery
Objective To analyze the efficacy of Danshen injection in preventing lower limb deep vein thrombosis in patients after general surgery.Methods A total of 110 patients undergoing general surgery were selected as observation subjects for the study,and divided into a study group and a control group using envelope lottery grouping method,each with 55 cases.The control group used conventional means to prevent lower limb deep vein thrombosis in the perioperative period,and the study group added Danshen injection to prevent lower limb deep vein thrombosis in the perioperative period based on the control group.Both groups were compared in terms of coagulation function related indicators[fibrinogen(FIB),activated partial thromboplastin time(APTT),and prothrombin time(PT)],hemorheological parameters(whole blood high shear viscosity and whole blood low shear viscosity),inflammatory factors[interleukin-6 and C-reactive protein(CRP)]before and after surgery,and the occurrence of lower-extremity deep vein thrombosis.Results After surgery,the levels of FIB,APTT and PT in the study group were better than those in the control group,and the difference was statistically significant(P<0.05).After surgery,the whole blood high shear viscosity in the study group was(3.38±0.23)mPa·s and the whole blood low shear viscosity was(16.06±1.47)mPa·s,which were lower than(4.24±0.52)and(18.72±2.84)mPa·s in the control group,and the difference was statistically significant(P<0.05).After surgery,the study group had IL-6 of(11.21±2.13)ng/L and CRP of(28.16±4.47)mg/L,which were lower than(20.24±4.52)ng/L and(36.72±5.82)mg/L in the control group,and the difference was statistically significant(P<0.05).The incidence of postoperative lower-extremity deep vein thrombosis in the study group was 3.64%,which was lower than 16.36%in the control group,and the difference was statistically significant(P<0.05).Conclusion Danshen injection has a high preventive effect on lower limb deep vein thrombosis in patients after general surgery,and can help patients improve coagulation function and hemorheological parameters,thus promoting the early recovery of patients.
Lower limb deep vein thrombosisGeneral surgeryDanshen injectionCoagulation functionInflammatory factors
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