Analysis of the efficacy of montelukast sodium combined with dextromethorphan hydrobromide in the treatment of postinfectious cough
Objective To analyze the effect of montelukast sodium combined with dextromethorphan hydrobromide in the treatment of postinfectious cough.Methods A total of 64 patients with postinfectious cough were selected as the study subjects.The patients were randomly divided into a conventional group and a study group,each consisting of 32 cases.The conventional group was treated with dextromethorphan hydrobromide,while the study group was treated with montelukast sodium combined with dextromethorphan hydrobromide.The treatment effects,incidence of adverse reactions,improvement of cough symptoms,and serum levels of inflammatory factors of the two groups were compared.Results The total effective rate of the study group and the conventional group were 96.88%and 75.00%,respectively,and the differences were statistically significant(χ2=6.335,P=0.012<0.05).The cough score of the study group was(1.31±0.65)points at 7 d after treatment,and(0.98±0.40)points at 14 d after treatment,both of which were lower than(1.88±0.97)and(1.39±0.73)points of the conventional group,and the differences were statistically significant(t=2.761,2.786,2.786;P=0.008,0.007<0.05).The levels of hypersensitive C-reactive protein in the study group were(15.08±2.17)and(6.38±1.07)mg/L,and the levels of procalcitonin in the study group were(0.38±0.04)and(0.04±0.02)ng/ml at 7 and 14 d after treatment,which were lower than(22.18±2.98),(11.56±1.80)mg/L and(0.78±0.18),(0.68±0.07)ng/ml in the conventional group,and the differences were statistically significant(t=10.895,13.993,12.271,and 49.730;P=0.000,0.000,0.000,and 0.000<0.05).The incidence of adverse reactions was 9.38%in the study group and 6.25%in the conventional group,and there was no significant difference between the two groups(χ2=0.216,P=0.641>0.05).Conclusion The combined treatment of montelukast sodium and dextromethorphan hydrobromide for patients with postinfectious cough is effective and has high clinical application value.
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