Effects of levosimendan combined with recombinant human brain natriuretic peptide on serum inflammatory factors and cardiac function in patients with acute heart failure
Objective To explore the effects of levosimendan combined with recombinant human brain natriuretic peptide on serum inflammatory factors and cardiac function in patients with acute heart failure(AHF).Methods The clinical data of 60 patients with AHF were retrospectively analyzed.According to the different treatment methods,they were divided into a control group(30 cases)and an observation group(30 cases).The control group received levosimendan treatment,on the basis of which,the observation group was combined with recombinant human brain natriuretic peptide treatment.Both groups were compared in terms of clinical effect,serum inflammatory factors[interleukin-10(IL-10),interleukin-17(IL-17),interleukin-6(IL-6),C-reactive protein(CRP)],cardiac function[cardiac index(CI),left ventricular end diastolic diameter(LVEDD),left ventricular ejection fraction(LVEF),and stroke volume(SV)]and adverse reactions.Results The total effective rate of the observation group was 96.67%,which was higher than 73.33%of the control group(P<0.05).After treatment,the observation group had higher IL-10 of(2.94±0.48)ng/L than(2.13±0.35)ng/L in the control group;the observation group had IL-17 of(16.21±3.22)ng/L,IL-6 of(3.63±0.89)ng/L and CRP of(10.18±2.07)mg/L,which were lower than(26.43±5.66)ng/L,(5.17±1.01)ng/L and(14.39±2.58)mg/L in the control group(P<0.05).After treatment,the observation group had lower LVEDD of(55.22±3.21)mm than(59.39±3.85)mm in the control group;the observation group had LVEF of(44.94±3.42)%,CI of(4.92±0.56)L/min and SV of(39.22±3.15)ml,which were higher than(41.15±2.63)%,(4.43±0.34)L/min and(36.23±2.45)ml in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion In patients with AHF,levosimendan combined with recombinant human brain natriuretic peptide therapy can regulate their inflammatory factors more quickly and promote the improvement of cardiac function with high safety.
Acute heart failureLevosimendanRecombinant human brain natriuretic peptideSerum inflammatory factorsCardiac function
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