Effects of Guanxinning tablets combined with atorvastatin on the clinical efficacy,NT-proBNP and hs-CRP levels in elderly patients with stable coronary heart disease
Objective To explore the effects of Guanxinning tablets combined with atorvastatin on the clinical efficacy,N-terminal pro-B-type natriuretic peptide(NT-proBNP)and hypersensitivity C-reactive protein(hs-CRP)levels in elderly patients with stable coronary heart disease(SCHD).Methods A total of 96 elderly patients with SCHD were selected,and divided into the study group and the control group by random number table method,each with 48 patients.The control group was treated with atorvastatin,and the study group was treated with Guanxinning tablets combined with atorvastatin.The clinical efficacy,cardiac function[left ventricular end-systolic diameter(LVESD),left ventricular end-diastolic diameter(LVEDD),left ventricular ejection fraction(LVEF)],NT-proBNP and hs-CRP levels before and after treatment of the two groups were compared.Results The total effective rate of the study group(95.83%)was higher than that of the control group(81.25%)(P<0.05).After treatment,LVEF was increased,LVESD and LVEDD were decreased in both groups;the study group had LVESD of(34.97±4.78)mm and LVEDD of(45.71±6.32)mm,which were lower than(38.21±4.35)and(49.96±5.24)mm in the control group;the study group had higher LVEF of(67.12±4.76)%than(62.38±5.91)%in the control group(P<0.05).After treatment,the levels of NT-proBNP and hs-CRP were decreased in both groups;the study group had NT-proBNP of(297.13±15.78)pg/ml and hs-CRP of(5.84±1.10)mg/L,which were lower than(340.26±18.49)pg/ml and(9.31±1.75)mg/L in the control group(P<0.05).Conclusion Guanxinning tablets combined with atorvastatin can improve the clinical efficacy,improve the levels of NT-proBNP and hs-CRP,and promote the recovery of cardiac function in elderly patients with SCHD.
Stable coronary heart disease in the elderlyGuanxinning tabletsAtorvastatinN-terminal pro-B-type natriuretic peptideHypersensitivity C-reactive protein
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