Effects of piperacillin sodium/sulbactam sodium and budesonide combined with terbutaline nebulized inhalation therapy on lung function,blood gas indicators,and inflammatory markers in patients with acute exacerbation of chronic obstructive pulmonary diseas
Objective To explore the effects of piperacillin sodium/sulbactam sodium and budesonide combined with terbutaline nebulized inhalation therapy on lung function,blood gas indicators,and inflammatory markers in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods 80 AECOPD patients were divided into an experimental group and a control group according to random numerical table,with 40 patients in each group.The control group was give nebulized inhalation of piperacillin sodium/sulbactam sodium and terbutaline,while the experimental group was give budesonide nebulized inhalation in addition to the control group.Both groups were compared in terms of clinical efficacy,lung function indicators[forced expiratory volume in one second(FEV1),forced vital capacity(FVC),and FEV1/FVC],blood gas indicators[arterial oxygen partial pressure(PaO2)and arterial carbon dioxide partial pressure(PaCO2)],inflammatory markers[C-reactive protein(CRP)and procalcitonin(PCT)].Results The experimental group had higher total effective rate of 92.50%than 72.50%in the control group,and the difference was statistically significant(P<0.05).After 5 d of treatment,the levels of FEV1,FVC and FEV1/FVC in both groups were improved compared with those before treatment;the experimental group had FEV1 of(2.12±0.41)L,FVC of(2.95±0.46)L and FEV1/FVC of(72.52±6.25)%,which were higher than(1.71±0.39)L,(2.65±0.41)L and(64.25±5.78)%in the control group;the difference was statistically significant(P<0.05).After 5 d of treatment,PaO2 level in both groups was higher than that before treatment,and the experimental group had higher PaO2 of(86.25±4.25)mm Hg(1 mm Hg=0.133 kPa)than(78.12±4.52)mm Hg in the control group.The difference was statistically significant(P<0.05).After 5 d of treatment,PaCO2 levels in both groups were lower than that before treatment,and the experimental group had lower PaCO2 of(43.25±4.25)mm Hg than(50.18±4.62)mm Hg in the control group.The difference was statistically significant(P<0.05).After 5 d of treatment,the serum CRP and PCT levels in both groups were lower than those before treatment;the experimental group had serum CRP of(8.21±1.24)mg/L and PCT of(0.12±0.03)ng/ml,which were lower than(14.75±2.02)mg/L and(0.21±0.05)ng/ml in the control group.The difference was statistically significant(P<0.05).Conclusion The treatment method of piperacillin sodium/sulbactam sodium and budesonide combined with terbutaline nebulized inhalation can effectively improve the condition of AECOPD patients,reduce inflammatory reactions in the body,improve blood gas indicators,and improve the lung function of patients.
Acute exacerbation of chronic obstructive pulmonary diseasePiperacillin sodium/sulbactam sodiumBudesonideTerbutalineNebulized inhalation
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