Effect of lansoprazole combined with duloxetine on symptoms and quality of life in patients with gastroesophageal reflux disease
Objective Gastroesophageal reflux disease(GERD)can have adverse effects on the physical and mental health of patients.This paper analyze the therapeutic effect of lansoprazole combined with duloxetine.Methods 50 patients with GERD were divided into a control group and a study group by random number table method,with 25 cases in each group.The control group was treated with lansoprazole,and the study group was treated with duloxetine based on the control group.The negative mood and symptoms,motor function of distal esophageal smooth muscle and quality of life were compared between the two groups.Results After treatment,the scores of Hamilton Anxiety Scale(HAMA),Hamilton Depression Scale(HAMD)and Gastroesophageal Reflux Disease Questionnaire(GerdQ)in both groups were lower than those before treatment;the study group had HAMA score of(6.37±1.41)points,HAMD score of(10.28±0.41)points and GerdQ score of(5.37±0.49)points,which were lower than(9.27±2.05),(13.27±0.62)and(9.25±2.41)points in the control group(P<0.05).After treatment,the lower esophageal sphincter resting pressure(LESP),lower esophageal sphincter relaxation rate(LESRR)and distal contractile integral(DCI)in both groups were higher than those before treatment;LESP,LESRR and DCI of the study group were(20.26±1.89)mm Hg(1 mm Hg=0.133 kPa),(99.37±8.14)%and(425.39±95.42)mm Hg·s·cm,which were higher than(17.13±1.12)mm Hg,(90.27±7.46)%and(299.25±92.34)mm Hg·s·cm in the control group(P<0.05).After treatment,the scores of heartburn,swallowing,drug influence and general health status in both groups were lower than those before treatment;the scores of heartburn,swallowing,drug influence and general health status in the study group were(2.19±0.11),(2.19±0.37),(2.35±0.15)and(2.38±0.16)points,which were lower than(5.73±1.42),(5.93±0.64),(4.96±1.41)and(4.83±0.43)points in the control group(P<0.05).Conclusion GERD patients not only have physical symptoms,and the psychological state of patients is also affected.The application of lansoprazole combined with duloxetine treatment program is conducive to promote the regression of the disease,improve the patient's bad mood,quality of life,which has high clinical application value and is worth promoting.
Gastroesophageal reflux diseaseLansoprazoleDuloxetineSymptomsQuality of life
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