Study on the feasibility of probiotics combined with anti-Hp regimen in the treatment of elderly patients with gastric ulcer and its influence on distribution of gut microbiota
Objective To explore the feasibility of probiotics combined with anti-Helicobacter pylori(Hp)regimen in the treatment of elderly patients with gastric ulcer and its influence on distribution of gut microbiota.Methods 60 elderly patients with gastric ulcers were divided into the observation group and the control group according to computer random grouping method,with 30 cases in each group.Patients in the observation group were treated with probiotics combined with anti-Hp regimen,while patients in the control group were treated with anti-Hp regimen.The distribution of gut microbiota,incidence of adverse reactions,and recurrence rates were compared between the two groups of patients.Results Before treatment,there was no significant difference in enterobacteriaceae,yeast and bifidobacterium between the two groups(P>0.05).After 14 d of treatment,the observation group had enterobacteriaceae of(7.98±0.12)lgCFU/g,yeast of(8.86±0.38)lgCFU/g,bifidobacterium of(8.24±0.38)lgCFU/g,which were higher than(7.65±0.16),(8.52±0.29)and(7.68±0.42)lgCFU/g in the control group,and the difference was statistically significant(P<0.05).When comparing the incidence of adverse reactions,it was found that there was no significant difference in data between the two groups(P>0.05).The recurrence rate of the observation group was 3.33%,which was lower than 20.00%of the control group,and the difference was statistically significant(P<0.05).Conclusion When improving the intervention methods for elderly gastric ulcer patients,choosing a combination of probiotics and anti-Hp regimen has significant therapeutic effects,which helps to improve the patient's gut microbiota and reduce ulcer recurrence.
Gastric ulcer in the elderlyAnti-Helicobacter pylori regimenProbioticsDistribution of gut microbiota
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