Study on clinical efficacy of vacuum sealing drainage combined with vancomycin-impregnated bone cement beads in the treatment of chronic osteomyelitis
Objective To confirm the clinical efficacy of vacuum sealing drainage combined with vancomycin-impregnated bone cement beads in the treatment of chronic osteomyelitis,so as to provide a new treatment plan for chronic osteomyelitis.Methods 88 patients with chronic osteomyelitis were selected.According to different clinical treatment methods,they were divided into a control group(treated with conventional drainage and antibiotic irrigation)and an observation group(treated with vacuum sealing drainage and vancomycin-impregnated bone cement beads),each with 44 cases.Both groups were compared in terms of perioperative indexes(duration of antibiotic use,incision healing time,hospital stay),visual analogue scale(VAS)score and serological indexes[serum C-reactive protein(CRP),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)].Results The duration of antibiotic use,incision healing time and hospital stay of the observation group were(18.01±2.52),(29.84±3.76)and(31.22±4.11)d,which were shorter than(28.96±3.91),(42.22±5.37)and(40.84±4.20)d of the control group.The difference was statistically significant(P<0.05).VAS scores of the observation group after 1 and 2 months of treatment were(2.42±1.03)and(2.25±0.98)points,which were lower than(3.14±1.25)and(1.74±0.87)points of the control group,and the difference was statistically significant(P<0.05).After 3 months of treatment,the VAS scores of the two groups were similar(P>0.05).After treatment,the levels of CRP,TNF-α and IL-6 in the observation group were(29.46±4.21)mg/L,(11.71±1.98)ng/L and(5.93±1.20)ng/L,which were lower than(35.61±6.89)mg/L,(16.48±2.14)ng/L and(7.84±1.31)ng/L in the control group,and the difference was statistically significant(P<0.05).Conclusion The combination of vacuum sealing drainage and vancomycin-impregnated bone cement beads for the treatment of chronic osteomyelitis is superior to conventional drainage combined with antibiotic irrigation in terms of duration of antibiotic use,incision healing time and hospital stay,pain level,and inflammatory indicators.This treatment plan shows good clinical efficacy and provides a new and effective treatment plan for the treatment of chronic osteomyelitis.
Vacuum sealing drainageVancomycin-impregnated bone cement beadsChronic osteomyelitis
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NSTL
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