Effects of different doses of atorvastatin calcium combined with aspirin for elderly patients with unstable angina pectoris of coronary heart disease and its influence on the levels of inflammatory factors
Objective To analyze the effects of aspirin combined with different doses of atorvastatin calcium for elderly patients with unstable angina pectoris of coronary heart disease and its influence on the levels of inflammatory factors.Methods A total of 100 elderly patients with unstable angina pectoris of coronary heart disease were selected as study subjects,and all were treated with atorvastatin calcium combined with aspirin.They were divided into a control group and an observation group according to different doses of atorvastatin calcium,each with 50 cases.The control group was treated with 10 mg atorvastatin calcium,and the observation group was treated with 20 mg atorvastatin calcium.Both groups were compared in terms of inflammatory factors[C-reactive protein(CRP),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),interleukin-4(IL-4)],blood lipid indicators[high density lipoprotein cholesterol(HDL-C),total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C)],cardiac function indicators[cardiac output(CO),stroke volume(SV),left ventricular ejection fraction(LVEF),left ventricular end-diastolic diameter(LVEDD)],therapeutic effect,and occurrence of adverse reactions.Results After treatment,the observation group had CRP of(6.06±2.06)mg/L,TNF-α of(1.33±0.37)ng/ml,and IL-6 of(117.26±26.52)pg/ml,which were lower than(10.11±2.43)mg/L,(1.89±0.41)ng/ml,and(141.52±29.33)pg/ml in the control group;the observation group had IL-4 of(2.53±0.12)pg/ml,which was higher than(1.99±0.23)pg/ml in the control group;there was statistical significance(P<0.05).After treatment,the observation group had HDL-C of(1.36±0.36)mmol/L,which was higher than(1.01±0.33)mmol/L in the control group;the observation group had TC of(3.83±0.87)mmol/L,TG of(1.88±0.52)mmol/L and LDL-C of(2.49±0.66)mmol/L,which were lower than(4.59±1.41),(2.52±0.75)and(3.01±0.81)mmol/L in the control group;there was statistical significance(P<0.05).After treatment,the observation group had CO of(5.72±1.11)L/min,SV of(72.82±9.77)ml and LVEF of(61.02±8.39)%,which were higher than(5.09±0.32)L/min,(64.51±8.03)ml and(56.32±7.27)%in the control group;the observation group had LVEDD of(51.33±0.45)mm,which was smaller than(51.83±0.57)mm in the control group;there was statistical significance(P<0.05).The total effective rate of the observation group was 98.00%,which was higher than 86.00%of the control group,and there was statistical significance(P<0.05).The incidence of adverse reactions in the observation group was significantly lower than that in the control group,and there was statistical significance(P<0.05).Conclusion Atorvastatin calcium combined with aspirin therapy is of significant value for elderly patients with unstable angina pectoris of coronary heart disease.Compared with low-dose(10 mg)atorvastatin calcium therapy,high-dose(20 mg)atorvastatin calcium therapy has more advantages,which can help to improve patients'inflammatory response and blood lipid level,regulate cardiac function,improve treatment effect and safety.
Coronary heart disease in the elderlyUnstable angina pectorisAspirinAtorvastatin calciumInflammatory factors
万方数据
维普
