Clinical advantages of carvedilol combined with enalapril in the treatment of hypertension with heart failure
Objective To explore the clinical advantages of carvedilol combined with enalapril in the treatment of hypertension with heart failure.Methods 200 patients with hypertension and heart failure were divided into a control group and a study group by random number table,each with 100 cases.The control group was treated with enalapril,and the study group was treated with carvedilol in addition to enalapril.The clinical efficacy,incidence of adverse reactions,blood pressure index,myocardial injury index,cardiac function index and quality of life score were compared between the two groups.Results The total effective rate of the study group was 98.00%,which was higher than 90.00%of the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).After treatment,the systolic blood pressure and diastolic blood pressure in both groups were significantly reduced compared with those before treatment;the study group had systolic blood pressure of(106.73±6.98)mm Hg(1 mm Hg=0.133 kPa)and diastolic blood pressure of(76.98±3.57)mm Hg,which were lower than(117.95±8.51)and(82.17±4.60)mm Hg in the control group(P<0.05).After treatment,the troponin I,creatine kinase isoenzyme and lactate dehydrogenase were significantly decreased in both groups compared with those before treatment,and the study group was lower than the control group(P<0.05).After treatment,N-terminal pro-B-type natriuretic peptide(NT-proBNP),myocardial performance index(Tei index)and left ventricular ejection fraction were significantly improved in both groups compared with those before treatment;the study group had NT-proBNP of(358.49±27.84)ng/ml and Tei index of(0.32±0.10),which were lower than(393.26±31.65)ng/ml and(0.44±0.11)in the control group;the study group had left ventricular ejection fraction of(59.36±5.28)%,which was higher than(53.17±4.52)%in the control group(P<0.05).After treatment,the scores of physiology,psychology,environment and social relations in both groups were significantly higher than those before treatment,and the study group was higher than the control group(P<0.05).Conclusion In the treatment of hypertension with heart failure,the combination of enalapril and carvedilol can enhance the therapeutic effect,control blood pressure more effectively,protect myocardial tissue,and improve cardiac function,which is conductive to improve the quality of life of patients.Drug combination does not increase the risk of adverse reactions,and the safety of the medication affected.
万方数据
维普
