A study on the predictive value of platelet parameters on the prognosis of non-cardiogenic cerebral infarction after anti-thrombotic therapy
Objective To study the predictive value of platelet parameters on the prognosis of non-cardiogenic cerebral infarction(NCCI)after anti-thrombotic therapy.Methods 71 patients with NCCI were selected.All patients completed detection of platelet parameters[platelet distribution width(PDW),mean platelet volume(MPV),platelet(PLT),PDW/PLT,MPV/PLT)before anti-thrombolysis on the first day of admission.After 7 d of anti-thrombotic therapy,all NCCI patients underwent PDW,MPV,PLT,PDW/PLT,MPV/PLT re-examination,which were expressed as PLT7,PDW7,MPV7,MPV7/PLT7,PDW7/PLT7,respectively.Modified Rankin scale(MRS)was used to evaluate the neurological function recovery of patients at 6 months.According to the results of prognosis evaluation,patients were divided into poor prognosis group(MRS score>2 points,10 cases)and good prognosis group(MRS score≤2 points,61 cases).(i)General information and blood test results of the two groups were compared;(ii)Multivariate Logistic regression was used to analyze the risk factors of poor prognosis in NCCI patients after 7 d of anti-thrombotic therapy;(iii)Receiver operating characteristic(ROC)curve was used to analyze the prognostic value of positive indicators in NCCI patients.Results After antithrombotic treatment,61 patients had good prognosis and 10 patients had poor prognosis.There was no significant difference in the comparison of age,gender,alcohol consumption,smoking,coronary heart disease,diabetes,hypertension,white blood cell count,uric acid,urea nitrogen,creatinine,homocysteine,low-density lipoprotein cholesterol,high-density lipoprotein cholesterol,triglycerides,total cholesterol,MPV,PDW,PLT7,and PDW/PLT levels between the two groups(P>0.05).The PLT in the poor prognosis group was(157.72±46.53)×109/L,which was significantly lower than(195.04±55.42)×109/L in the good prognosis group;MPV/PLT in the poor prognosis group was(0.77±0.14)×10-10 fl/L,which was significantly higher than(0.61±0.23)×10-10 fl/L in the good prognosis group.The difference was significant(P<0.05).In the poor prognosis group,MPV7,MPV7/PLT7,PDW7 and PDW7/PLT7 were(14.72±4.07)fl,(0.73±0.23)×10-10 fl/L,(11.63±1.48)fl and(0.92±0.39)×10-10 fl/L,which were significantly higher than(12.29±3.26)fl,(0.52±0.21)×10-10 fl/L,(9.81±1.58)fl and(0.71±0.25)×10-10 fl/L in the good prognosis group,and the difference was significant(P<0.05).The factors(PLT,MPV/PLT,PDW7,PDW7/PLT7,MPV7,MPV7/PLT7)that showed significant differences in univariate analysis were included in multivariate logistic regression analysis,and the results showed that MPV7 was a risk factor for poor prognosis in NCCI patients[OR=7.668,95%CI=(1.526,38.527),P=0.012<0.05].The ROC curve showed that MPV7 had a predictive value for the prognosis of NCCI patients.With MPV=10.13 fl as the critical value,the area under the curve(AUC)of MPV7 for predicting a poor prognosis in NCCI patients was 0.786[95%CI=(0.677,0.896),P=0.001<0.05],the sensitivity was 83.33%,and the specificity was 69.50%.Conclusion MPV value after 7 d of antithrombotic therapy is a risk factor for poor prognosis in patients with NCCI,and can help predict the prognosis of NCCI.
Non-cardiogenic cerebral infarctionAnti-thrombotic therapyPlatelet distribution widthMean platelet volumePlatelet count
万方数据
维普
