Analysis of clinical efficacy of compound glycyrrhizin combined with Xiaoyin granule in the treatment of pityriasis rosea
Objective To explore the clinical efficacy of compound glycyrrhizin combined with Xiaoyin granule in the treatment of pityriasis rosea.Methods A total of 78 patients with pityriasis rosea were divided into a control group and a study group according to the method of random number table,each with 39 patients.The control group was treated with compound glycyrrhizin,and the study group was treated with Xiaoyin granule on the basis of compound glycyrrhizin.The therapeutic effect,symptom resolution time,symptom score,serum inflammatory factor index,sleep status index and quality of life score were compared between the two groups.Results The total effective rate of the study group was 97.44%,which was higher than 82.05%of the control group(P<0.05).The resolution time of pruritus,papula and pigmentation in the study group were(4.12±0.76),(3.29±0.81)and(4.37±0.89)d,which were shorter than(5.30±0.93),(4.32±0.97)and(5.64±1.02)d in the control group(P<0.05).After treatment,the scores of pruritus,papula and pigmentation in both groups were significantly reduced compared with those before treatment;in the study group,the pruritus scores was(1.17±0.39)points,the papula score was(1.06±0.31)points and the pigmentation score was(1.16±0.40)points,which were lower than(1.58±0.43),(1.52±0.48)and(1.61±0.45)points in the control group(P<0.05).After treatment,the levels of C-reactive protein and interleukin-6 in both groups were significantly lower than those before treatment,and the study group was lower than the control group(P<0.05).After treatment,the sleep latency,actual sleep duration and sleep quality scores in both groups were significantly improved compared with those before treatment,and sleep latency,actual sleep duration and sleep quality scores in the study group were better than those in the control group(P<0.05).After treatment,the scores of physiology,psychology,environment and social relations in both groups were significantly higher than those before treatment,and the study group was higher than the control group(P<0.05).Conclusion In the treatment of pityriasis rosea,the combination of compound glycyrrhizin and Xiaoyin granule can not only reduce the inflammatory reaction,but also make the symptoms subside faster and better,it can also improve their sleep quality and quality of life.
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