Correlation between Mycoplasma pneumonia infection and acute attack of bronchial asthma in children
Objective To explore the correlation between Mycoplasma pneumonia(MP)infection and acute attack of bronchial asthma in children.Methods 50 children in acute stage of bronchial asthma and 50 children in remission stage of bronchial asthma were selected as the subjects of this study.50 children in remission stage of bronchial asthma were included in the control group,and 50 children in acute stage of bronchial asthma were included in the experimental group,all of whom were subjected to the tests of serology,lung function,immune function.Comparison was made on MP infection rates,antibody titers,lung function[forced expiratory volume in one second(FEV1),forced vital capacity(FVC),and FEV1/FVC],immune function(CD4+,CD8+,CD4+/CD8+)between the two groups,as well as various indicators[eosinophil cationic protein(ECP),interleukin-5(IL-5),eosinophil(EOS)count,immunoglobulin E(IgE)]of MP positive and negative children in the experimental group.Results The MP positive rate in the experimental group was 72.00%and the percentage of antibody titer 1∶320 was 83.33%,which were higher than 34.00%and 29.41%in the control group;the MP negative rate in the experimental group was 28.00%and the percentage of antibody titer 1∶160 was 16.67%,which were lower than 66.00%and 70.59%in the control group.The difference was statistically significant(P<0.05).In the experimental group,ECP,IL-5,EOS count and IgE of MP-positive children were(12.49±1.17)μg/L,(3.91±0.16)ng/L,(518.23±36.67)×106/L and(365.62±78.42)IU/ml,which were higher than(8.16±1.47)μg/L,(2.41±0.17)ng/L,(402.68±49.62)×106/L and(289.61±44.23)IU/ml of MP-negative children,and the difference was statistically significant(P<0.05).CD4+and CD4+/CD8+in the experimental group were(29.48±2.96)%and(1.28±0.42),which were significantly lower than(34.41±2.43)%and(1.58±0.52)in the control group;the experimental group had CD8+of(31.59±2.19)%,which was higher than(23.91±1.65)%in the control group;the difference was statistically significant(P<0.05).FEV1,FVC and FEV1/FVC in the experimental group were(1.48±0.24)L,(2.19±0.23)L and(67.26±6.62)%,which were lower than(1.93±0.21)L,(2.44±0.24)L and(79.16±5.17)%in the control group.The difference was statistically significant(P<0.05).Conclusion Most of the children with acute attacks of bronchial asthma are accompanied by MP infection,which significantly reduces the lung function of the children,causes immune disorders,and exacerbates the symptoms of bronchial asthma,so MP infection can be used as an important basis for the clinical diagnosis and treatment of acute attacks of bronchial asthma in children.
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